Department of Radiology Brigham and Women's Hospital 75 Francis St, Boston, MA 02115.
Radiology. 2014 Dec;273(3):631-3. doi: 10.1148/radiol.14142033.
Burgess et al ( 1 ) present intriguing results of repetitive transient opening of the blood-brain barrier (BBB) in a transgenic mouse model of advanced Alzheimer disease (AD). The results underscore the potential of using magnetic resonance (MR) imaging-guided focused ultrasound and microbubble ultrasonography (US) contrast agents for the disruption of the BBB as a potential long-term therapy to reduce amyloid plaque burden and improve cognitive performance. This daring conclusion that is based on an experimental animal model should now be confirmed in humans. Considering that the technology is commercially available and given the immense clinical need, clinical trials in this AD treatment should be initiated as soon as possible.
Burgess 等人（1）展示了在晚期阿尔茨海默病（AD）转基因小鼠模型中，血脑屏障（BBB）反复短暂开放的有趣结果。这些结果强调了使用磁共振（MR）成像引导聚焦超声和微泡超声造影（US）对比剂破坏 BBB 的潜力，作为一种潜在的长期治疗方法，以减少淀粉样斑块负担并改善认知功能。这一基于实验动物模型的大胆结论现在应该在人类中得到证实。考虑到该技术已商业化，并且存在巨大的临床需求，应尽快启动针对该 AD 治疗的临床试验。
