Department of Mechanical Engineering, Sharif University of Technology, Tehran, PO Box: 11365-11155, Iran.
Department of Electrical Engineering, York University, Toronto, ON M3J1P3, Canada.
Biosensors (Basel). 2016 Jun 14;6(2):25. doi: 10.3390/bios6020025.
This paper scrutinizes the magnetic field effect to deliver the superparamagnetic nanoparticles (SPMNs) through the Blood Brain Barrier (BBB). Herein we study the interaction between the nanoparticle (NP) and BBB membrane using Molecular Dynamic (MD) techniques. The MD model is used to enhance our understanding of the dynamic behavior of SPMNs crossing the endothelial cells in the presence of a gradient magnetic field. Actuation of NPs under weak magnetic field offers the great advantage of a non-invasive drug delivery without the risk of causing injury to the brain. Furthermore, a weak magnetic portable stimulator can be developed using low complexity prototyping techniques. Based on MD simulation results in this paper, SPMNs can cross the cell membrane while experiencing very weak mechanical forces in the range of pN. This study also derives guidelines for the design of the SPMNs dedicated to crossing the BBB using external magnetic fields.
本文探讨了磁场对超顺磁纳米颗粒（SPMNs）通过血脑屏障（BBB）的输送作用。文中我们使用分子动力学（MD）技术研究了纳米颗粒（NP）与 BBB 膜之间的相互作用。该 MD 模型有助于我们深入了解在存在梯度磁场的情况下 SPMNs 穿过内皮细胞的动态行为。在弱磁场下对 NPs 进行激励具有非侵入式药物输送的巨大优势，而不会有损伤大脑的风险。此外，可以使用低复杂度的原型制作技术来开发弱磁便携式刺激器。基于本文中的 MD 模拟结果，SPMNs 可以在经历非常微弱的机械力（在 pN 范围内）的情况下穿过细胞膜。本研究还为使用外部磁场设计专门用于穿越 BBB 的 SPMNs 提供了指导。
