Pradjatmo Heru, Dasuki Djaswadi, Anwar Mohammad, Mubarika Sofia
Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia E-mail :
Asian Pac J Cancer Prev. 2014;15(21):9479-85. doi: 10.7314/apjcp.2014.15.21.9479.
Cancer initiation and progression are controlled by genetic and epigenetic events. One epigenetic process which is widely known is DNA methylation, a cause of gene silencing. If a gene is silenced the protein which it encodes will not expressed.
The study design was a prospective-cohort study, conducted at Sardjito hospital, Yogyakarta, Indonesia.
A total of 69 cases were analyzed in this study. The data showed that the methylation status of BRCA1 in EOC was positive in 89.9%, with clear protein expression of BRCA1 in 31.9%. Methylation status and expression of BRCA1 were not prognosticators of EOC patients. Menarche, CA125 level, clinical stage and residual tumor were independent factors for prognosis.
癌症的发生和发展受遗传和表观遗传事件控制。一种广为人知的表观遗传过程是DNA甲基化，它是基因沉默的一个原因。如果一个基因被沉默，它所编码的蛋白质将不会表达。
本研究为前瞻性队列研究，在印度尼西亚日惹的萨迪托医院进行。
本研究共分析了69例病例。数据显示，EOC中BRCA1的甲基化状态阳性率为89.9%，BRCA1蛋白清晰表达率为31.9%。BRCA1的甲基化状态和表达不是EOC患者的预后指标。初潮、CA125水平、临床分期和残留肿瘤是预后的独立因素。
