一种基于尼罗蓝的红外荧光探针：对过表达环氧合酶-2的肿瘤进行成像。
A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2.
作者信息
Wang Benhua, Fan Jiangli, Wang Xianwu, Zhu Hao, Wang Jingyun, Mu Huiying, Peng Xiaojun
机构信息
State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian 116024, China.
出版信息
Chem Commun (Camb). 2015 Jan 14;51(4):792-5. doi: 10.1039/c4cc08915d.
The first Golgi-localized cyclooxygenase-2 (COX-2)-specific near-infrared (NIR) fluorescent probe, Niblue-C6-IMC, able to detect cancer cells, was designed. Importantly, Niblue-C6-IMC preferentially labeled the tumors in a mouse tumor model with deep tissue penetration capacity. It may be a promising molecular tool for guiding tumor resection during surgery.
首个能够检测癌细胞的高尔基体定位环氧化酶-2（COX-2）特异性近红外（NIR）荧光探针Niblue-C6-IMC被设计出来。重要的是，Niblue-C6-IMC在具有深部组织穿透能力的小鼠肿瘤模型中优先标记肿瘤。它可能是一种在手术期间指导肿瘤切除的有前景的分子工具。
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