利用一种可激活的近红外荧光探针在体实时比色检测内源性β-半乳糖苷酶活性。
In vivo ratiometric tracking of endogenous β-galactosidase activity using an activatable near-infrared fluorescent probe.
机构信息
State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China.
出版信息
Chem Commun (Camb). 2019 Oct 10;55(82):12308-12311. doi: 10.1039/c9cc06869d.
Herein, we developed a dual-channel and light-up near-infrared fluorescent probe for ratiometric sensing of β-galactosidase (β-gal) activity. The well-designed probe, which shows ratiometric optical response with a significant red-shift (from 575 nm to 730 nm), was successfully applied to detect endogenous β-gal activity in SKOV-3 cells and tumor-bearing mice.
在这里，我们开发了一种双通道和点亮近红外荧光探针，用于β-半乳糖苷酶（β-gal）活性的比率感应。该设计良好的探针具有显著的红移（从 575nm 到 730nm）的比率光学响应，成功地应用于检测 SKOV-3 细胞和荷瘤小鼠内源性β-gal 活性。
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