State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China.
Chem Commun (Camb). 2019 Oct 10;55(82):12308-12311. doi: 10.1039/c9cc06869d.
Herein, we developed a dual-channel and light-up near-infrared fluorescent probe for ratiometric sensing of β-galactosidase (β-gal) activity. The well-designed probe, which shows ratiometric optical response with a significant red-shift (from 575 nm to 730 nm), was successfully applied to detect endogenous β-gal activity in SKOV-3 cells and tumor-bearing mice.
在这里，我们开发了一种双通道和点亮近红外荧光探针，用于β-半乳糖苷酶（β-gal）活性的比率感应。该设计良好的探针具有显著的红移（从 575nm 到 730nm）的比率光学响应，成功地应用于检测 SKOV-3 细胞和荷瘤小鼠内源性β-gal 活性。
