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单纯颈淋巴结转移胸段食管鳞癌患者放化疗的疗效及预后分析

Efficacy and prognostic analysis of chemoradiotherapy in patients with thoracic esophageal squamous carcinoma with cervical lymph nodal metastasis alone.

作者信息

Zhang Peng, Xi Mian, Zhao Lei, Li Qiao-Qiao, He Li-Ru, Liu Shi-Liang, Shen Jing-Xian, Liu Meng-Zhong

机构信息

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China.

Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, People's Republic of China.

出版信息

Radiat Oncol. 2014 Nov 26;9:256. doi: 10.1186/s13014-014-0256-9.

DOI:10.1186/s13014-014-0256-9
PMID:25424871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4251839/
Abstract

BACKGROUND

The prognostic factors of thoracic esophageal squamous carcinoma with cervical lymph nodal metastasis (CLNM) have not been specifically investigated. This study was performed to analyze the efficacy and prognostic factors of chemoradiotherapy for thoracic esophageal carcinoma with CLNM alone.

METHODS

From 2002 to 2011, 139 patients with inoperable esophageal cancer who underwent chemoradiotherapy at the Sun Yat-Sen University were retrospectively analyzed. Median radiation doses were 60 Gy (range: 50-68 Gy). Univariate and multivariate analyses were performed to compare overall survival (OS) and progression-free survival (PFS).

RESULTS

The 1- and 3-year OS rates were 68.2% and 27.9%, respectively. The 1- and 3-year PFS rates were 51.9% and 20.1%, respectively. The multivariate analysis demonstrated that response to treatment, T stage, pathological grade, and laterality of cervical lymph nodal metastases were independent prognostic factors for thoracic esophageal carcinoma with CLNM.

CONCLUSIONS

Concurrent chemoradiotherapy is an important and hopeful treatment option for patients with esophageal cancer with CLNM alone. Our study has revealed that response to treatment, T stage, pathological grade and laterality of cervical lymph nodal metastases are significant prognostic factors for long-term survival.

摘要

背景

胸段食管鳞状细胞癌伴颈部淋巴结转移（CLNM）的预后因素尚未得到专门研究。本研究旨在分析单纯胸段食管癌伴CLNM患者接受放化疗的疗效及预后因素。

方法

回顾性分析2002年至2011年在中山大学接受放化疗的139例无法手术切除的食管癌患者。中位放疗剂量为60 Gy（范围：50 - 68 Gy）。进行单因素和多因素分析以比较总生存期（OS）和无进展生存期（PFS）。

结果

1年和3年总生存率分别为68.2%和27.9%。1年和3年无进展生存率分别为51.9%和20.1%。多因素分析表明，治疗反应、T分期、病理分级以及颈部淋巴结转移的侧别是胸段食管癌伴CLNM的独立预后因素。

结论

同步放化疗是单纯胸段食管癌伴CLNM患者重要且有希望的治疗选择。我们的研究表明，治疗反应、T分期、病理分级以及颈部淋巴结转移的侧别是长期生存的重要预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4aa/4251839/b76b0d109860/13014_2014_256_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4aa/4251839/d334c34d5c16/13014_2014_256_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4aa/4251839/b07e4173e2e1/13014_2014_256_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4aa/4251839/b76b0d109860/13014_2014_256_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4aa/4251839/d334c34d5c16/13014_2014_256_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4aa/4251839/b07e4173e2e1/13014_2014_256_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4aa/4251839/b76b0d109860/13014_2014_256_Fig3_HTML.jpg

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