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当寻求 HIV-1 疫苗效力的相关因素时，中和筛分析的重要性。

Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy.

机构信息

a Laboratory for AIDS Vaccine Research & Development; Department of Surgery; Duke University Medical Center; Durham, NC USA.

出版信息

Hum Vaccin Immunother. 2014;10(8):2507-11. doi: 10.4161/hv.28950.

DOI:10.4161/hv.28950
PMID:25424964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4896798/
Abstract

This commentary describes a rationale for the use of breakthrough viruses from clinical trial participants to assess neutralizing antibodies as a correlate of HIV-1 vaccine efficacy. The rationale is based on principles of a genetic sieve analysis, where the 2 analyses may be cooperative for delineating neutralizing antibodies as a mechanistic correlate of protection.

摘要

本述评描述了使用来自临床试验参与者的突破性病毒来评估中和抗体作为 HIV-1 疫苗效力的相关指标的原理。该原理基于遗传筛选分析的原则，这两种分析方法可能会合作，以确定中和抗体作为保护机制的相关指标。