锡生藤乙醇提取物的植物化学与药理学研究
Phytochemical and Pharmacological Investigation of Ethanol Extract of Cissampelos pareira.
作者信息
Reza H M, Shohel M, Aziz Sadia B, Pinaz Farzana I, Uddin M F, Al-Amin M, Khan I N, Jain Preeti
机构信息
Department of Pharmacy, North South University, Dhaka, Bangladesh.
Department of Pharmacy, University of Science and Technology Chittagong, Bangladesh.
出版信息
Indian J Pharm Sci. 2014 Sep;76(5):455-8.
In this study, the ethanol extract of Cissampelos pareira has been evaluated. The extract was tested for analgesic properties using both hot plate and acetic acid-induced writhing methods. Antiinflammatory effect was investigated using two different doses of 250 and 500 mg/kg body weight on Evans rats by carrageenan-induced paw edema test. The antipyretic activity was evaluated using Brewer's yeast-induced pyrexia in Wistar rats. The phytochemical screening of the extract of Cissampelos pareira exhibited the presence of several phytochemical compounds including saponins, gums and carbohydrates, reducing sugars, alkaloids and terpenoids. Ethanol extract of Cissampelos pareira exhibited significant analgesic, antiinflammatory and antipyretic activity in a dose-dependent manner. The results obtained from these studies confirm its therapeutic value against diseases caused by various pain and fever.
在本研究中，对锡生藤的乙醇提取物进行了评估。使用热板法和乙酸诱导扭体法对该提取物的镇痛特性进行了测试。通过角叉菜胶诱导的爪肿胀试验，以250和500mg/kg体重这两种不同剂量对埃文斯大鼠研究其抗炎作用。使用啤酒酵母诱导Wistar大鼠发热来评估其解热活性。锡生藤提取物的植物化学筛选显示存在几种植物化学化合物，包括皂苷、树胶和碳水化合物、还原糖、生物碱和萜类化合物。锡生藤乙醇提取物以剂量依赖性方式表现出显著的镇痛、抗炎和解热活性。从这些研究中获得的结果证实了其对由各种疼痛和发热引起的疾病的治疗价值。
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