贯叶连翘叶提取物对 Wistar 白化大鼠的抗炎活性。
Anti-inflammatory activity of Premna corymbosa (Burm.f.) Rottl. & Willd. leaves extracts in Wistar albino rats.
机构信息
Department of Pharmacology, Al Shifa College of Pharmacy, Poonthavanam, Kizhattur Perinthalmanna, Malappuram - 679325 Kerala State, India.
出版信息
Asian Pac J Trop Med. 2011 Jul;4(7):510-3. doi: 10.1016/S1995-7645(11)60136-3.
OBJECTIVE
To evaluate the acute toxicity and to investigate the effect of Premna corymbosa ethanolic extract (PCEE) at doses of 200 and 400 mg/kg body weight in acute and chronic models of inflammation in experimental animals.
METHODS
In the acute toxicity study, a single dose of PCEE of 2 000 mg/kg body weight, p.o. was administered and observed for 48 h. In acute models as egg albumin induced paw edema and chronic model as cotton pellet methods was followed.
RESULTS
In acute models, egg albumin induced paw edema PCEE significantly (P<0.01) inhibited the edema formation. In chronic model, cotton pellet induced granuloma formation in rats PCEE significantly (P<0.01) reduced the granuloma formation with percentage inhibition of 35.17% and 50.38 % respectively.
CONCLUSIONS
The present study establishes the antiinflammatory activity of Premna corymbosa leaves.
目的
评估醉鱼草乙醇提取物（PCEE）的急性毒性，并研究其在动物急性和慢性炎症模型中 200 和 400mg/kg 体重剂量的作用。
方法
在急性毒性研究中，给予单剂量 2000mg/kg 体重的 PCEE，po，观察 48 小时。采用卵白蛋白诱导的爪肿胀和慢性模型（棉粒法）进行急性模型研究。
结果
在急性模型中，PCEE 显著抑制卵白蛋白诱导的爪肿胀（P<0.01）。在慢性模型中，PCEE 显著减少大鼠棉球诱导的肉芽肿形成（P<0.01），抑制率分别为 35.17%和 50.38%。
结论
本研究确立了醉鱼草叶的抗炎活性。
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