Hui Dawn S, Shavelle David M, Cunningham Mark J, Matthews Ray V, Starnes Vaughn A
Tex Heart Inst J. 2014 Oct 1;41(5):469-76. doi: 10.14503/THIJ-13-3757. eCollection 2014 Oct.
The development of transcatheter aortic valve implantation (TAVI) has increased the use of balloon aortic valvuloplasty (BAV) in treating aortic stenosis. We evaluated our use of BAV in an academic tertiary referral center with a developing TAVI program. We reviewed 69 consecutive stand-alone BAV procedures that were performed in 62 patients (mean age, 77 ± 10 yr; 62% men; baseline mean New York Heart Association functional class, 3 ± 1) from January 2009 through December 2012. Enrollment for the CoreValve(®) clinical trial began in January 2011. We divided the study cohort into 2 distinct periods, defined as pre-TAVI (2009-2010) and TAVI (2011-2012). We reviewed clinical, hemodynamic, and follow-up data, calculating each BAV procedure as a separate case. Stand-alone BAV use increased 145% from the pre-TAVI period to the TAVI period. The mean aortic gradient reduction was 13 ± 10 mmHg. Patients were successfully bridged as intended to cardiac or noncardiac surgery in 100% of instances and to TAVI in 60%. Five patients stabilized with BAV subsequently underwent surgical aortic valve replacement with no operative deaths. The overall in-hospital mortality rate (17.4%) was highest in emergent patients (61%). The implementation of a TAVI program was associated with a significant change in BAV volumes and indications. Balloon aortic valvuloplasty can successfully bridge patients to surgery or TAVI, although least successfully in patients nearer death. As TAVI expands to more centers and higher-risk patient groups, BAV might become integral to collaborative treatment decisions by surgeons and interventional cardiologists.
经导管主动脉瓣植入术(TAVI)的发展增加了球囊主动脉瓣成形术(BAV)在治疗主动脉瓣狭窄中的应用。我们在一个开展TAVI项目的学术性三级转诊中心评估了BAV的使用情况。我们回顾了2009年1月至2012年12月期间在62例患者(平均年龄77±10岁;62%为男性;基线平均纽约心脏协会心功能分级为3±1级)中连续进行的69例单纯BAV手术。CoreValve®临床试验于2011年1月开始入组。我们将研究队列分为两个不同时期,即TAVI前(2009 - 2010年)和TAVI期(2011 - 2012年)。我们回顾了临床、血流动力学和随访数据,将每例BAV手术作为一个单独病例进行计算。从TAVI前时期到TAVI时期,单纯BAV的使用增加了145%。平均主动脉压差降低了13±10 mmHg。100%的患者成功地按计划过渡到心脏或非心脏手术,60%的患者成功过渡到TAVI。5例通过BAV病情稳定的患者随后接受了外科主动脉瓣置换术,无手术死亡病例。总体住院死亡率(17.4%)在急诊患者中最高(61%)。TAVI项目的实施与BAV的手术量和适应证的显著变化相关。球囊主动脉瓣成形术可以成功地使患者过渡到手术或TAVI,尽管在接近死亡的患者中成功率最低。随着TAVI扩展到更多中心和更高风险的患者群体,BAV可能成为外科医生和介入心脏病学家联合治疗决策中不可或缺的一部分。