多能干细胞衍生的神经干细胞：从基础研究到应用。
Pluripotent stem cell-derived neural stem cells: From basic research to applications.
机构信息
Masahiro Otsu, Department of Chemistry, Kyorin University School of Medicine, Shinkawa, Mitaka , Tokyo 181-8611, Japan.
出版信息
World J Stem Cells. 2014 Nov 26;6(5):651-7. doi: 10.4252/wjsc.v6.i5.651.
Abstract
Basic research on pluripotent stem cells is designed to enhance understanding of embryogenesis, whereas applied research is designed to develop novel therapies and prevent diseases. Attainment of these goals has been enhanced by the establishment of embryonic stem cell lines, the technological development of genomic reprogramming to generate induced-pluripotent stem cells, and improvements in vitro techniques to manipulate stem cells. This review summarizes the techniques required to generate neural cells from pluripotent stem cells. In particular, this review describes current research applications of a simple neural differentiation method, the neural stem sphere method, which we developed.
摘要
多能干细胞的基础研究旨在增强对胚胎发生的理解，而应用研究旨在开发新的治疗方法和预防疾病。通过建立胚胎干细胞系、基因组重编程技术来产生诱导多能干细胞，以及改进体外技术来操纵干细胞，这些目标得到了加强。本综述总结了从多能干细胞中生成神经细胞所需的技术。特别是，本综述描述了我们开发的一种简单的神经分化方法——神经球方法的当前研究应用。
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本文引用的文献
1
Promotion of mouse embryonic stem cell differentiation by Rho kinase inhibitor Y-27632.
Neurosci Lett. 2014 Sep 5;579:58-63. doi: 10.1016/j.neulet.2014.07.011. Epub 2014 Jul 17.
2
Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders.
Mol Brain. 2014 Feb 14;7:12. doi: 10.1186/1756-6606-7-12.
3
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation.
J Biol Chem. 2014 Mar 28;289(13):9430-9. doi: 10.1074/jbc.M113.512350. Epub 2014 Feb 7.
4
Effects of heat shock on survival, proliferation and differentiation of mouse neural stem cells.
Neurosci Res. 2014 Feb;79:13-21. doi: 10.1016/j.neures.2013.11.005. Epub 2013 Dec 4.
5
Integrated platform for production and purification of human pluripotent stem cell-derived neural precursors.
Stem Cell Rev Rep. 2014 Apr;10(2):151-61. doi: 10.1007/s12015-013-9482-z.
6
Human embryonic stem cells derived by somatic cell nuclear transfer.
Cell. 2013 Jun 6;153(6):1228-38. doi: 10.1016/j.cell.2013.05.006. Epub 2013 May 15.
7
Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects in hESCs and patient-specific iPSCs.
Cell Rep. 2013 Apr 25;3(4):1140-52. doi: 10.1016/j.celrep.2013.03.025. Epub 2013 Apr 11.
8
Generation of human induced pluripotent stem cells from cord blood cells.
J Stem Cells. 2011;6(3):101-8.
9
Proteomic identification of differentially expressed genes during differentiation of cynomolgus monkey (Macaca fascicularis) embryonic stem cells to astrocyte progenitor cells in vitro.
Biochim Biophys Acta. 2013 Feb;1834(2):601-10. doi: 10.1016/j.bbapap.2012.12.002. Epub 2012 Dec 8.
10
Induced pluripotent stem cells: past, present, and future.
Cell Stem Cell. 2012 Jun 14;10(6):678-684. doi: 10.1016/j.stem.2012.05.005.
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