Auboyer C, Bouletreau P, Brinquin L, Lepape A, Motin J
Poumon Coeur. 1977;33(6):365-73.
Mendelson's syndrome is discussed with a review of the literature and presentation of 27 personal cases studies. Accidental aspiration of gastric fluid occurs primarily during anesthesia, in cranial trauma victims, and in toxic coma patients. Tissue damage is proportional to the acidity and the quantity of aspirated fluid. The initial clinical manifestations are often serious, sometimes leading to acute respiratory distress syndrom with pulmonary edema. Frequent infectious complications, often with anaerobic microbes, are deciding factors in the prognosis. Artificial ventilation with positive pressure (sometimes continuous) is often necessary. Administration of corticosteroids at high doses is likely favorable. Prophylactic administration of antibiotics is initially directed against anaerobic agents. The prevention of this serious syndrome should be a primary concern of anesthesiologists and physicians treating comatous patients.
本文通过文献综述和27例个人病例研究，对门德尔松综合征进行了讨论。胃液误吸主要发生在麻醉期间、颅脑外伤患者和中毒昏迷患者中。组织损伤与误吸液体的酸度和量成正比。最初的临床表现往往很严重，有时会导致急性呼吸窘迫综合征伴肺水肿。频繁的感染并发症，通常伴有厌氧菌，是预后的决定性因素。常需进行正压人工通气（有时是持续通气）。大剂量使用皮质类固醇可能有益。预防性使用抗生素最初针对厌氧菌。预防这种严重综合征应是麻醉医生和治疗昏迷患者的医生的首要关注点。
