Qin Fang-Min, Liu Bai-Lian, Zhang Ying, Zhou Guang-Xiong
a Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research , College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University , Guangzhou 510632 , P.R. China.
Nat Prod Res. 2015;29(7):633-7. doi: 10.1080/14786419.2014.980249. Epub 2014 Nov 26.
A novel triterpenoid 3α,16β,23,24-tetrahydroxy-28-nor-ursane-12,17,19,21-tetraen (1) was isolated from the fruits of Gardenia jasminoides var. radicans Makino. The structure of the new compounds was elucidated on the basis of spectroscopic analysis including MS and NMR data. Compound 1 was in vitro tested for cytostatic activity on human throat cancer (Hep-2) cell line by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide method and showed mild anticancer activity with the IC50 of 31.2 μM.
从水栀子果实中分离出一种新型三萜类化合物3α,16β,23,24-四羟基-28-降乌苏烷-12,17,19,21-四烯(1)。基于包括质谱和核磁共振数据在内的光谱分析阐明了该新化合物的结构。通过3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐法对化合物1进行体外人喉癌(Hep-2)细胞系的细胞生长抑制活性测试,结果显示其具有轻度抗癌活性,IC50为31.2 μM。