从黄栀子渗出液中分离得到的细胞毒 3,4-裂环环阿屯烷型三萜。

Cytotoxic 3,4-seco-cycloartane triterpenes from the exudate of Gardenia tubifera.

机构信息

Research Centre of Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

出版信息

J Nat Prod. 2010 Jan;73(1):51-4. doi: 10.1021/np900658t.

DOI:10.1021/np900658t

PMID:20028108

Abstract

Four new 3,4-seco-cycloartanes, gardenoins A-D (1-4), together with the known compound secaubryenol (5), were isolated from the exudate of Gardenia tubifera. The structures of 1-4 were elucidated on the basis of spectroscopic analysis. The cytotoxic activity of compounds 1-4 was evaluated against five human tumor cell lines.

摘要

从栀子（Gardenia tubifera）的渗出物中分离得到了四个新的 3,4-裂环环阿屯烷，即gardenoins A-D（1-4），以及已知化合物 secaubryenol（5）。根据光谱分析确定了 1-4 的结构。评估了化合物 1-4 对五种人肿瘤细胞系的细胞毒性活性。