Nanjing University of Chinese Medicine, Nanjing 210000, PR China.
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Fitoterapia. 2013 Jul;88:7-11. doi: 10.1016/j.fitote.2013.03.025. Epub 2013 Apr 6.
Three new iridoid glucosides, 6″-O-trans-feruloylgenipin gentiobioside (1), 2'-O-trans-caffeoylgardoside (2), jasmigeniposide A (3), and one new bis-iridoid glucoside, jasmigeniposide B (4), along with six known analogues (5-10), were isolated from the fruit of Gardenia jasminoides. Their structures were established on the basis of spectroscopic analyses and chemical methods. Anti-virus activity of isolated compounds were evaluated in vitro and only compound 9 showed moderate inhibitory activity against H1N1 with 50% effective concentration (EC50) value of 104.36 μM, and selective index (SI) value greater than 4.79.
从栀子果实中分离得到了 3 个新的裂环环烯醚萜葡萄糖苷，分别为 6″-O-反式阿魏酰京尼平龙胆二糖苷（1）、2′-O-反式咖啡酰澳洲茄边碱（2）、栀子京尼平苷 A（3）和 1 个新的双裂环环烯醚萜葡萄糖苷，栀子京尼平苷 B（4），以及 6 个已知类似物（5-10）。基于光谱分析和化学方法确定了它们的结构。对分离得到的化合物进行了体外抗病毒活性评价，只有化合物 9 对 H1N1 表现出中等抑制活性，半数有效浓度（EC50）值为 104.36 μM，选择指数（SI）值大于 4.79。
