Bustos Patricia, Amigo Hugo, Vásquez Alejandra, Vargas Claudio
Rev Med Chil. 2014 May;142(5):579-86. doi: 10.4067/S0034-98872014000500005.
Metabolic syndrome is a risk factor for cardiovascular diseases and cancer. Its frequency is increasing steadily Aim: To evaluate the prevalence of metabolic syndrome (MS) and its components in a 10-year tracking study of young adults.
Concurrent cohort study of subjects born between 1974 and 1978. They were evaluated between 2000 and 2002 and between 2010 and 2012 to determine the frequency of MS and its components (high blood glucose, waist circumference [WC], triglycerides, blood pressure and low HDL cholesterol), according to ATP III criteria. Attrition was handled using the reciprocal of the probability of remaining in the study.
During the first evaluation, the prevalence of metabolic syndrome was 9.3%, confidence interval (CI): 7.5-11.1), with no gender differences. Ten years later, the prevalence of MS increased significantly to 27.6% (CI: 24.7-29.9) and was more common in women than men (30.4 and 23.8% respectively, p < 0.014). The components of MS also increased from one period to another: hyperglycemia, from 5.2% (CI: 4-7) to 24.4% (CI: 22-27); high triglyceride levels from 17.6% (CI: 15-20) to 35.3% (CI: 32-38); high blood pressure from 14.7 (CI: 13-18) to 30.2% (IC: 28-33) and high WC: 16.9% (CI: 15-19) to 41.5% (CI: 39-45). In both evaluations, there was a greater frequency of high triglycerides and high blood pressure among men, and greater frequency of low HDL and high WC among women. Hyperglycemia only showed differences by gender in the second measurement, and was greater among men.
There was a marked increase in metabolic syndrome and its components in a 10-year interval, which is a warning sign of future cardiovascular risk.
代谢综合征是心血管疾病和癌症的危险因素。其发病率正在稳步上升。目的：在一项针对年轻人的10年跟踪研究中评估代谢综合征（MS）及其组成部分的患病率。
对1974年至1978年出生的受试者进行同期队列研究。在2000年至2002年以及2010年至2012年期间对他们进行评估，以根据ATP III标准确定MS及其组成部分（高血糖、腰围[WC]、甘油三酯、血压和低高密度脂蛋白胆固醇）的发生率。使用留在研究中的概率的倒数来处理失访问题。
在首次评估时，代谢综合征的患病率为9.3%，置信区间（CI）：7.5 - 11.1），无性别差异。十年后，MS的患病率显著增加至27.6%（CI：24.7 - 29.9），且在女性中比男性更常见（分别为30.4%和23.8%，p < 0.014）。MS的组成部分在两个时期之间也有所增加：高血糖从5.2%（CI：4 - 7）增至24.4%（CI：22 - 27）；高甘油三酯水平从17.6%（CI：15 - 20）增至35.3%（CI：32 - 38）；高血压从14.7%（CI：13 - 18）增至30.2%（IC：28 - 33），高WC从16.9%（CI：15 - 19）增至41.5%（CI：39 - 45）。在两次评估中，男性中高甘油三酯和高血压的发生率更高，女性中低高密度脂蛋白和高WC的发生率更高。高血糖仅在第二次测量中显示出性别差异，且男性中更高。
在10年期间代谢综合征及其组成部分显著增加，这是未来心血管风险的一个警示信号。
