Garcia-Larsen Vanessa, Bustos Patricia, Amigo Hugo, Potts James, Rona Roberto J
Respiratory Epidemiology, Occupational Medicine, and Public Health Group, National Heart & Lung Institute Imperial College London, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, UK.
BMC Pulm Med. 2014 Dec 18;14:206. doi: 10.1186/1471-2466-14-206.
The association between impaired lung function and cardiovascular disease (CVD) risk factors has been shown in adults. However, there is little evidence of such an association in young adults, particularly from South America, where the burden of CVD and chronic obstructive pulmonary disease (COPD) is as high as that observed in more developed countries. We therefore investigated the relation between CVD risk factors including metabolic syndrome (MS), and lung function status in young adults from Chile.
970 subjects from a sample of 998 adults born between 1974 and 1978 in Limache, Chile, were studied. A Spanish translation of the European Community Respiratory Health Survey (ECRHS) questionnaire was used. Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were measured. Weight, height, waist circumference (WC), blood pressure, Homeostatic model assessment (HOMA-IR), triglycerides, high density lipoprotein (HDL), glycaemia, and metabolic syndrome (MS) were also assessed.
The prevalence of MS was 11.8%. A lower FEV1 and lower FVC were associated with having MS (β-coefficient -0.13; 95% Confidence Interval [CI] -0.21 to -0.05, and β-coefficient -0.18; 95% CI -0.27 to -0.09, respectively). Both spirometric measures were also negatively associated with having an elevated HOMA-IR (β-coefficient for FEV1 -0.08; 95% CI -0.13 to -0.03, and β-coefficient for FVC -0.11; 95% CI -0.17 to -0.05). In males only, a lower FEV1 and FVC were associated with having elevated triglycerides (β-coefficient highest vs. lowest tertile -0.13, 95% CI -0.24 to -0.03, and β-coefficient -0.13, 95% CI -0.25 to -0.01, respectively). In women, a higher FEV1 and FVC were statistically significantly related to having higher levels of HDL. Ventilatory function was unrelated to hypertension or WC in this population.
In this population-based study of young adults, a poorer ventilatory function was associated with many CVD risk factors. Endeavours to understand better causality issues of such associations are warranted.
在成年人中，肺功能受损与心血管疾病（CVD）风险因素之间的关联已得到证实。然而，在年轻成年人中，尤其是来自南美洲的年轻成年人中，几乎没有此类关联的证据，而南美洲的心血管疾病和慢性阻塞性肺疾病（COPD）负担与较发达国家观察到的负担一样高。因此，我们调查了包括代谢综合征（MS）在内的心血管疾病风险因素与智利年轻成年人肺功能状况之间的关系。
对来自智利利马切的998名1974年至1978年出生的成年人样本中的970名受试者进行了研究。使用了欧洲共同体呼吸健康调查（ECRHS）问卷的西班牙语翻译版本。测量了1秒用力呼气量（FEV1）和用力肺活量（FVC）。还评估了体重、身高、腰围（WC）、血压、稳态模型评估（HOMA-IR）、甘油三酯、高密度脂蛋白（HDL）、血糖和代谢综合征（MS）。
代谢综合征的患病率为11.8%。较低的FEV1和较低的FVC与患有代谢综合征相关（β系数分别为-0.13；95%置信区间[CI]-0.21至-0.05，以及β系数为-0.18；95%CI-0.27至-0.09）。两种肺量计测量指标也与较高的HOMA-IR呈负相关（FEV1的β系数为-0.08；95%CI-0.13至-0.03，FVC的β系数为-0.11；95%CI-0.17至-0.05）。仅在男性中，较低的FEV1和FVC与甘油三酯升高相关（β系数最高三分位数与最低三分位数相比分别为-0.13，95%CI-0.24至-0.03，以及β系数为-0.13，95%CI-0.25至-0.01）。在女性中，较高的FEV1和FVC与较高水平的HDL在统计学上显著相关。在该人群中，通气功能与高血压或腰围无关。
在这项基于人群的年轻成年人研究中，较差的通气功能与许多心血管疾病风险因素相关。有必要努力更好地理解此类关联的因果关系问题。
