Sipes S L, Weiner C P, Gellhaus T M, Goodspeed J D
Perinatal Research Laboratory, University of Iowa College of Medicine, Iowa City.
Obstet Gynecol. 1989 Jun;73(6):934-7. doi: 10.1097/00006250-198906000-00005.
Two groups of women were studied in a prospective longitudinal fashion to determine the effects of a 2.5-hour infusion of magnesium sulfate upon the renin-angiotensin system. Serum magnesium concentration, angiotensin-converting enzyme concentration, and plasma renin activity were measured at uniform intervals in women with either preeclampsia or preterm labor. Plasma renin activity was significantly lower (3.9 +/- 2.2 versus 6.1 +/- 1.8 ng/mL/minute; P = .004) and angiotensin-converting enzyme significantly higher (47.1 +/- 14 versus 34.0 +/- 10 U/mL; P = .008) in women with preeclampsia than in those with preterm labor. Magnesium infusion was associated with a sustained decline in plasma renin activity in preeclamptic women (P = .003). A transient decline in angiotensin-converting enzyme (P = .009) was observed in women with preeclampsia, but not with preterm labor. In contrast to the sustained change in plasma renin activity, angiotensin-converting enzyme concentration returned to baseline activity levels by 2.5 hours. A nonsignificant negative relationship (P = .06) was noted between angiotensin-converting enzyme and gestational age in subjects with preeclampsia. We conclude that a short-term infusion of magnesium sulfate leads to a sustained decline in plasma renin activity in preeclamptic women, but exerts no sustained effect on angiotensin-converting enzyme in women with either preeclampsia or preterm labor.
以前瞻性纵向研究方式对两组女性进行了研究，以确定静脉输注2.5小时硫酸镁对肾素 - 血管紧张素系统的影响。在患有先兆子痫或早产的女性中，以统一的时间间隔测量血清镁浓度、血管紧张素转换酶浓度和血浆肾素活性。与早产女性相比，先兆子痫女性的血浆肾素活性显著降低（3.9±2.2对6.1±1.8 ng/mL/分钟；P = 0.004），血管紧张素转换酶显著升高（47.1±14对34.0±10 U/mL；P = 0.008）。输注硫酸镁与先兆子痫女性血浆肾素活性的持续下降相关（P = 0.003）。在先兆子痫女性中观察到血管紧张素转换酶短暂下降（P = 0.009），但早产女性未出现这种情况。与血浆肾素活性的持续变化相反，血管紧张素转换酶浓度在2.5小时时恢复到基线活性水平。在先兆子痫患者中，血管紧张素转换酶与孕周之间存在无统计学意义的负相关关系（P = 0.06）。我们得出结论，短期输注硫酸镁可导致先兆子痫女性血浆肾素活性持续下降，但对患有先兆子痫或早产的女性的血管紧张素转换酶没有持续影响。
