Fuentes A, Goldkrand J W
Am J Obstet Gynecol. 1987 Jun;156(6):1375-9. doi: 10.1016/0002-9378(87)90003-2.
Angiotensin-converting enzyme is a peptidase involved in the formation of angiotensin II and the inactivation of bradykinin. In a previous study we found elevated angiotensin-converting enzyme activity in women with pregnancy-induced hypertension prior to magnesium sulfate therapy and lower levels during therapy. This prospective study was undertaken in order to determine if angiotensin-converting enzyme activity indeed decreased after magnesium sulfate therapy. Sixteen patients with pregnancy-induced hypertension were studied before and during magnesium sulfate therapy. Angiotensin-converting enzyme activity was found to decrease 1 to 8 hours into therapy and then plateau between 9 and 24 hours. Possible mechanisms for this observation are discussed.
血管紧张素转换酶是一种肽酶，参与血管紧张素II的形成和缓激肽的失活。在之前的一项研究中，我们发现妊娠高血压综合征妇女在硫酸镁治疗前血管紧张素转换酶活性升高，治疗期间活性降低。进行这项前瞻性研究是为了确定硫酸镁治疗后血管紧张素转换酶活性是否确实降低。对16例妊娠高血压综合征患者在硫酸镁治疗前和治疗期间进行了研究。结果发现，治疗开始后1至8小时血管紧张素转换酶活性降低，然后在9至24小时之间趋于平稳。本文讨论了这一观察结果可能的机制。
