Marusic Zlatko, Kos Marina, Labinac-Peteh Loredana, Perković Bečić Manuela, Vranić Semir, Luzar Boštjan
Department of Pathology, Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia.
Bosn J Basic Med Sci. 2014 Sep 22;14(4):205-8. doi: 10.17305/bjbms.2014.4.116.
We report two new cases of cystic fibroepithelioma of Pinkus together with immunohistochemical features and analyze the presence of cystic changes in a series of 16 classical fibroepitheliomas of Pinkus. Our findings show that the formation of cystic spaces is most probably caused by ischemic degeneration of stromal fenestrations, rather than by central tumor cell necrosis. This finding is supported by lack of CD34 positive blood vessels in edematous and hyalinized stromal fenestrations undergoing transformation into cystic spaces, as opposed to the uninvolved stromal fenestrations. Therefore, it is probably more accurate to refer to this process as pseudocystic stromal degeneration rather than true cyst formation. Also, two out of 16 classical Pinkus fibroepitheliomas exhibited focal pseudocystic changes in 50% and 10% of the tumor, respectively, demonstrating that this degenerative process can be found, rarely and focally, in classical cases as well.
我们报告了2例新的Pinkus囊性纤维上皮瘤病例及其免疫组化特征，并分析了一系列16例经典Pinkus纤维上皮瘤中的囊性改变情况。我们的研究结果表明，囊性腔隙的形成很可能是由基质窗孔的缺血性退变引起的，而非中央肿瘤细胞坏死所致。这一发现得到了以下证据的支持：在正转变为囊性腔隙的水肿和玻璃样变的基质窗孔中缺乏CD34阳性血管，这与未受累的基质窗孔形成对比。因此，将这一过程称为假性囊性基质退变而非真性囊肿形成可能更为准确。此外，16例经典Pinkus纤维上皮瘤中有2例分别在肿瘤的50%和10%区域出现局灶性假性囊性改变，表明这种退变过程在经典病例中也很少见且为局灶性出现。
