碳酸钾介导通过迈克尔环化反应合成官能化的4-取代-2-氨基-3-氰基-4H-色烯
K2CO3-mediated synthesis of functionalised 4-substituted-2-amino-3-cyano-4H-chromenes via Michael-cyclization reactions.
作者信息
He Yanyang, Hu Rong, Tong Rongsheng, Li Fengqiong, Shi Jianyou, Zhang Mei
机构信息
Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Pharmaceutical Department of Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu 610072, China.
出版信息
Molecules. 2014 Nov 25;19(12):19253-68. doi: 10.3390/molecules191219253.
An efficient approach for the synthesis of functionalized 4-substituted-2-amino-3-cyano-4H-chromenes moderate to high yields (up to 98%) has been achieved via a tandem K2CO3 catalyzed conjugate addition-cyclization reaction of malononitrile and a range of Knoevenagel adducts previously formed from oxindole, pyrazolone, nitromethane, N,N-dimethylbarbituric acid or indanedione. This methodology differs from the previous classical methods in its simplicity and ready availability of the catalyst.
通过碳酸钾催化丙二腈与一系列先前由氧化吲哚、吡唑啉酮、硝基甲烷、N,N-二甲基巴比妥酸或茚二酮形成的克脑文盖尔加合物进行串联共轭加成-环化反应，已实现了一种高效合成官能化4-取代-2-氨基-3-氰基-4H-色烯的方法，产率适中至高（高达98%）。该方法在催化剂的简单性和易获得性方面与先前的经典方法不同。
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