Rajasekhar Mekala, Maheswara Rao Kunda Uma, Sundar Chereddy Syama, Reddy Nemallapudi Bakthavatchala, Nayak Sandip Kumar, Reddy Cirandur Suresh
Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Chem Pharm Bull (Tokyo). 2012;60(7):854-8. doi: 10.1248/cpb.c12-00160.
A simple and efficient one pot synthesis of 2-amino-4H-chromen-4-yl phosphonate derivatives has been accomplished by the condensation of salicylaldehyde, malononitrile/ethylcyanoacetate and triethyl phosphite/trimethyl phosphite in the presence of molecular iodine as catalyst in water at room temperature. All the reactions were very clean and the products were obtained in very good to excellent yields. The title compounds are characterized by IR, 1H-, 13C-, 31P-NMR and mass spectra, also studied their antimicrobial and antioxidant activity.
通过在室温下于水中，以分子碘为催化剂，使水杨醛、丙二腈/氰基乙酸乙酯与亚磷酸三乙酯/亚磷酸三甲酯缩合，实现了2-氨基-4H-色烯-4-基膦酸酯衍生物的简单高效一锅法合成。所有反应都非常纯净，产物的产率很高至优异。通过红外光谱、1H-、13C-、31P-核磁共振谱和质谱对标题化合物进行了表征，还研究了它们的抗菌和抗氧化活性。
