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Microwave-assisted synthesis of HYNIC protected analogue for 99mTc labeled antibody.

作者信息

García María F, Calzada Victoria, Camacho Ximena, Goicochea Enzo, Gambini Juan Pablo, Quinn Thomas P, Porcal Williams, Cabral Pablo

机构信息

Laboratorio de Radiofarmacia, Centro de Investigaciones Nucleares, Mataojo 2055, Facultad de Ciencias, Universidad de la Republica, 11400 Montevideo, Uruguay.

出版信息

Curr Radiopharm. 2014;7(2):84-90. doi: 10.2174/1874471007666141128160449.

DOI:10.2174/1874471007666141128160449
PMID:25429778
Abstract

We described herein a simple and efficient microwave assisted synthesis of HYNIC analogues. Two different activated esters of HYNIC, the hydrazine protected with a trifluoroacetyl group (5) and the free hydrazine (6) were conjugated to the monoclonal antibody Nimotuzumab. Technetium-99m radiolabeling of Nimotuzumab was achieved with high efficiency using 5 and 6 derivates. The NHS-HYNIC-Tfa derivate allowed better labeling yields during longer times of preservation of the conjugated antibody.

摘要

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