Chan Alexandre, Lim Eunice, Ng Terence, Shih Vivianne, Quek Richard, Cheung Yin Ting
Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science 4, Block S4, Singapore, 117543, Singapore,
Support Care Cancer. 2015 Jun;23(6):1709-17. doi: 10.1007/s00520-014-2533-4. Epub 2014 Nov 29.
Limited data are available on how symptom burden affects health-related quality of life (HRQoL) in patients with sarcoma. This study aims to describe the symptom burden, HRQoL, and medication use in adult sarcoma patients.
A single-center, cross-sectional study was conducted, and 79 patients were evaluated using three tools: the Rotterdam Symptom Checklist (RSCL), the Beck Anxiety Inventory (BAI), and the Functional Assessment of Cancer Therapy scale-General (FACT-G). Patients' demographic and clinical information, medication history, and use of concomitant medications were recorded. The proportion of patients with clinically significant RSCL score for a particular symptom was compared with the percentage of patients receiving medication for that symptom.
The mean age was 57.3 ± 15.2 years, with majority of the patients diagnosed with stromal tumor (46.8 %), leiomyosarcoma (15.2 %), and liposarcoma (10.1 %). The most prevalent physical symptoms experienced were tiredness (2.38 ± 1.00), lack of energy (2.04 ± 1.02), and difficulty sleeping (2.00 ± 1.15). The most common psychological symptoms experienced were irritability (1.92 ± 1.01), worrying (1.86 ± 0.90), and anxiety (1.68 ± 0.74). Few (6.3 %) patients received hypnotics while 33.0 % of patients reported difficulty sleeping. A proportion of patients (27.9 %) reported experiencing lack of appetite with only 1.3 % received appetite stimulants.
Adult sarcoma patients experience significant physiological and psychological symptom burden, which has a strong negative impact on HRQoL, with a number of physiological symptoms undertreated with pharmacotherapy.
关于症状负担如何影响肉瘤患者健康相关生活质量（HRQoL）的数据有限。本研究旨在描述成年肉瘤患者的症状负担、HRQoL及药物使用情况。
开展了一项单中心横断面研究，使用三种工具对79例患者进行评估：鹿特丹症状清单（RSCL）、贝克焦虑量表（BAI）和癌症治疗功能评估量表通用版（FACT-G）。记录患者的人口统计学和临床信息、用药史及合并用药情况。将特定症状RSCL临床显著评分患者的比例与接受该症状治疗药物患者的百分比进行比较。
平均年龄为57.3±15.2岁，大多数患者被诊断为间质瘤（46.8%）、平滑肌肉瘤（15.2%）和脂肪肉瘤（10.1%）。最常见的身体症状为疲倦（2.38±1.00）、精力不足（2.04±1.02）和睡眠困难（2.00±1.15）。最常见的心理症状为易怒（1.92±1.01）、担忧（1.86±0.90）和焦虑（1.68±0.74）。很少有患者（6.3%）使用催眠药，而33.0%的患者报告有睡眠困难。一部分患者（27.9%）报告有食欲缺乏，只有1.3%的患者接受了食欲刺激剂治疗。
成年肉瘤患者经历着显著的生理和心理症状负担，这对HRQoL有强烈的负面影响，许多生理症状未得到药物治疗。
