Kolodny N H, Gragoudas E S, D'Amico D J, Albert D M
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
Surv Ophthalmol. 1989 May-Jun;33(6):502-14. doi: 10.1016/0039-6257(89)90052-0.
Proton magnetic resonance imaging (1H MRI) has emerged as a clinically useful tool for the diagnosis of intraocular tumors. During the last four years 1H MRI characteristics, including spin-lattice relaxation times (T1) and spin-spin relaxation times (T2), have been established for several types of tumors. The introduction of surface coils to the imaging process has significantly improved the quality of intraocular MR images, leading some clinicians to suggest that 1H MR images are preferable to CT scans. Another MRI technique, in which sodium-23 (23Na) is imaged rather than protons, is now under development as tool for intraocular diagnosis. The potential of 23Na MRI depends upon the high concentration and "visibility" of sodium in the vitreous body, and upon the apparent differences in sodium behavior in normal cells vs. tumor cells. The metabolism of normal ocular tissues and intraocular tumors may be probed noninvasively with phosphorus-31 MR spectroscopy (31P MRS). Much progress has been made during the last few years in understanding the appearance of 31P MR spectra of many types of healthy and diseased cells and tissues. Clinical application of this technique to the diagnosis and monitoring of intraocular tumors following conservative treatment will be dependent upon the development of spectroscopy techniques that collect information from the volume of interest (tumor) only.
质子磁共振成像（1H MRI）已成为诊断眼内肿瘤的一种临床有用工具。在过去四年中，已经确定了几种类型肿瘤的1H MRI特征，包括自旋晶格弛豫时间（T1）和自旋 - 自旋弛豫时间（T2）。将表面线圈引入成像过程显著提高了眼内MR图像的质量，使得一些临床医生认为1H MR图像优于CT扫描。另一种MRI技术，即对钠 - 23（23Na）而非质子进行成像，目前正在作为眼内诊断工具进行开发。23Na MRI的潜力取决于玻璃体中钠的高浓度和“可见性”，以及正常细胞与肿瘤细胞中钠行为的明显差异。可以用磷 - 31磁共振波谱（31P MRS）对正常眼组织和眼内肿瘤的代谢进行无创探测。在过去几年中，在理解多种类型健康和患病细胞及组织的31P MR波谱表现方面已经取得了很大进展。该技术在保守治疗后对眼内肿瘤的诊断和监测中的临床应用将取决于仅从感兴趣体积（肿瘤）收集信息的波谱技术的发展。
