Jubelirer S J
W V Med J. 1989 May;85(5):183-6.
Small-cell carcinoma of the lung has been shown to be quite responsive to chemotherapy. Unfortunately, these responses are often short in duration, and long-term, disease-free survival is infrequent. This review of tumor registry records of all patients with small-cell carcinoma of the lung treated at Charleston Area Medical Center (CAMC) from 1962 to 1983 showed that 21 of 500 (four per cent) survived 30 months or longer. Eighteen patients had limited-extent disease. Although the majority of patients received chemotherapy alone or chemotherapy and radiation, there were survivors in all treatment groups (i.e. surgery alone or radiotherapy alone). Six of the 21 long-term survivors eventually had relapses occurring as late as 88 months after diagnosis. The overall poor survival of patients with small-cell lung cancer suggests a need for the development of novel initial approaches to therapy.
肺癌小细胞癌已被证明对化疗相当敏感。不幸的是，这些反应的持续时间往往很短，长期无病生存的情况并不常见。对1962年至1983年在查尔斯顿地区医疗中心（CAMC）接受治疗的所有肺癌小细胞癌患者的肿瘤登记记录进行的回顾显示，500名患者中有21名（4%）存活了30个月或更长时间。18名患者的疾病范围有限。尽管大多数患者仅接受化疗或化疗与放疗，但所有治疗组（即仅手术或仅放疗）均有幸存者。21名长期幸存者中有6人最终出现复发，最晚在诊断后88个月。肺癌小细胞癌患者总体生存情况较差，这表明需要开发新的初始治疗方法。
