de Borges R J, Garcia-Tamayo J, Zaitzman M
Department of Pathology, Central University of Venezuela School of Medicine, Caracas.
Acta Cytol. 1989 May-Jun;33(3):314-8.
Inclusion bodies were previously found in Papanicolaou smears of patients infected by the human papillomavirus (HPV). To ascertain their origin, 12 biopsies from patients with colposcopic evidence of papillomatous lesions were studied by cytology and electron microscopy. In several instances, koilocytotic atypias and electron-dense masses included within epithelial cells were observed. Some of these epithelial cells appeared to be surrounded by other cells in a sort of concentric arrangement. The electron-dense masses were composed of intermediate filaments, vacuoles and electron-dense material. They seemed to be dyskeratotic cells. They can be compared with apoptotic bodies and may be related to a disturbance of the involucrin expression caused by the HPV infection.
先前在感染人乳头瘤病毒（HPV）的患者巴氏涂片检查中发现了包涵体。为确定其来源，对12例有阴道镜检查显示乳头瘤样病变证据的患者活检组织进行了细胞学和电子显微镜研究。在一些病例中，观察到挖空细胞异型性以及上皮细胞内的电子致密团块。其中一些上皮细胞似乎被其他细胞以一种同心排列的方式包围着。电子致密团块由中间丝、空泡和电子致密物质组成。它们似乎是角化不良细胞。它们可与凋亡小体相比较，可能与HPV感染引起的内披蛋白表达紊乱有关。
