针对减少社区中老年人跌倒恐惧的锻炼

Exercise for reducing fear of falling in older people living in the community.

作者信息

Kendrick Denise, Kumar Arun, Carpenter Hannah, Zijlstra G A Rixt, Skelton Dawn A, Cook Juliette R, Stevens Zoe, Belcher Carolyn M, Haworth Deborah, Gawler Sheena J, Gage Heather, Masud Tahir, Bowling Ann, Pearl Mirilee, Morris Richard W, Iliffe Steve, Delbaere Kim

机构信息

School of Medicine, Division of Primary Care, University of Nottingham, Floor 13, Tower Building, University Park, Nottingham, UK, NG7 2RD.

出版信息

Cochrane Database Syst Rev. 2014 Nov 28;2014(11):CD009848. doi: 10.1002/14651858.CD009848.pub2.

Abstract

BACKGROUND

Fear of falling is common in older people and associated with serious physical and psychosocial consequences. Exercise (planned, structured, repetitive and purposive physical activity aimed at improving physical fitness) may reduce fear of falling by improving strength, gait, balance and mood, and reducing the occurrence of falls.

OBJECTIVES

To assess the effects (benefits, harms and costs) of exercise interventions for reducing fear of falling in older people living in the community.

SEARCH METHODS

We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register (July 2013), the Central Register of Controlled Trials (CENTRAL 2013, Issue 7), MEDLINE (1946 to July Week 3 2013), EMBASE (1980 to 2013 Week 30), CINAHL (1982 to July 2013), PsycINFO (1967 to August 2013), AMED (1985 to August 2013), the World Health Organization International Clinical Trials Registry Platform (accessed 7 August 2013) and Current Controlled Trials (accessed 7 August 2013). We applied no language restrictions. We handsearched reference lists and consulted experts.

SELECTION CRITERIA

We included randomised and quasi-randomised trials that recruited community-dwelling people (where the majority were aged 65 and over) and were not restricted to specific medical conditions (e.g. stroke, hip fracture). We included trials that evaluated exercise interventions compared with no intervention or a non-exercise intervention (e.g. social visits), and that measured fear of falling. Exercise interventions were varied; for example, they could be 'prescriptions' or recommendations, group-based or individual, supervised or unsupervised.

DATA COLLECTION AND ANALYSIS

Pairs of review authors independently assessed studies for inclusion, assessed the risk of bias in the studies and extracted data. We combined effect sizes across studies using the fixed-effect model, with the random-effect model used where significant statistical heterogeneity was present. We estimated risk ratios (RR) for dichotomous outcomes and incidence rate ratios (IRR) for rate outcomes. We estimated mean differences (MD) where studies used the same continuous measures and standardised mean differences (SMD) where different measures or different formats of the same measure were used. Where possible, we performed various, usually prespecified, sensitivity and subgroup analyses.

MAIN RESULTS

We included 30 studies, which evaluated 3D exercise (Tai Chi and yoga), balance training or strength and resistance training. Two of these were cluster-randomised trials, two were cross-over trials and one was quasi-randomised. The studies included a total of 2878 participants with a mean age ranging from 68 to 85 years. Most studies included more women than men, with four studies recruiting women only. Twelve studies recruited participants at increased risk of falls; three of these recruited participants who also had fear of falling.Poor reporting of the allocation methods in the trials made it difficult to assess the risk of selection bias in most studies. All of the studies were at high risk of performance and detection biases as there was no blinding of participants and outcome assessors and the outcomes were self reported. Twelve studies were at high risk of attrition bias. Using GRADE criteria, we judged the quality of evidence to be 'low' for fear of falling immediately post intervention and 'very low' for fear of falling at short or long-term follow-up and all other outcomes.Exercise interventions were associated with a small to moderate reduction in fear of falling immediately post intervention (SMD 0.37 favouring exercise, 95% confidence interval (CI) 0.18 to 0.56; 24 studies; 1692 participants, low quality evidence). Pooled effect sizes did not differ significantly between the different scales used to measure fear of falling. Although none of the sensitivity analyses changed the direction of effect, the greatest reduction in the size of the effect was on removal of an extreme outlier study with 73 participants (SMD 0.24 favouring exercise, 95% CI 0.12 to 0.36). None of our subgroup analyses provided robust evidence of differences in effect in terms of either the study primary aim (reduction of fear of falling or other aim), the study population (recruitment on the basis of increased falls risk or not), the characteristics of the study exercise intervention or the study control intervention (no treatment or alternative intervention). However, there was some weak evidence of a smaller effect, which included no reduction, of exercise when compared with an alternative control.There was very low quality evidence that exercise interventions may be associated with a small reduction in fear of falling up to six months post intervention (SMD 0.17, 95% CI -0.05 to 0.38; four studies, 356 participants) and more than six months post intervention (SMD 0.20, 95% CI -0.01 to 0.41; three studies, 386 participants).Very low quality evidence suggests exercise interventions in these studies that also reported on fear of falling reduced the risk of falling measured either as participants incurring at least one fall during follow-up or the number of falls during follow-up. Very low quality evidence from four studies indicated that exercise interventions did not appear to reduce symptoms of depression or increase physical activity. The only study reporting the effects of exercise interventions on anxiety found no difference between groups. No studies reported the effects of exercise interventions on activity avoidance or costs. It is important to remember that our included studies do not represent the totality of the evidence of the effect of exercise interventions on falls, depression, anxiety or physical activity as our review only includes studies that reported fear of falling.

AUTHORS' CONCLUSIONS: Exercise interventions in community-dwelling older people probably reduce fear of falling to a limited extent immediately after the intervention, without increasing the risk or frequency of falls. There is insufficient evidence to determine whether exercise interventions reduce fear of falling beyond the end of the intervention or their effect on other outcomes. Although further evidence from well-designed randomised trials is required, priority should be given to establishing a core set of outcomes that includes fear of falling for all trials examining the effects of exercise interventions in older people living in the community.

摘要

背景

害怕跌倒在老年人中很常见,且与严重的身体和心理社会后果相关。运动(旨在提高身体素质的有计划、有结构、重复且有目的的身体活动)可通过增强力量、改善步态、平衡和情绪以及减少跌倒的发生来减轻对跌倒的恐惧。

目的

评估运动干预对减少社区居住老年人跌倒恐惧的效果(益处、危害和成本)。

检索方法

我们检索了Cochrane骨、关节和肌肉创伤小组专业注册库(2013年7月)、Cochrane对照试验中心注册库(CENTRAL 2013年第7期)、MEDLINE(1946年至2013年7月第3周)、EMBASE(1980年至2013年第30周)、护理及健康照护领域数据库(CINAHL,1982年至2013年7月)、心理学文摘数据库(PsycINFO,1967年至2013年8月)、联合和补充医学数据库(AMED,1985年至2013年8月)、世界卫生组织国际临床试验注册平台(2013年8月7日访问)和当前对照试验库(2013年8月7日访问)。我们未设语言限制。我们手工检索了参考文献列表并咨询了专家。

选择标准

我们纳入了招募社区居住人群(其中大多数年龄在65岁及以上)且不限于特定医疗状况(如中风、髋部骨折)的随机和半随机试验。我们纳入了评估运动干预与无干预或非运动干预(如社交拜访)相比,并测量跌倒恐惧的试验。运动干预形式多样;例如,它们可以是“处方”或建议,基于小组或个体,有监督或无监督。

数据收集与分析

由两位综述作者独立评估纳入研究,评估研究中的偏倚风险并提取数据。我们使用固定效应模型合并各研究的效应量,在存在显著统计异质性时使用随机效应模型。我们估计二分结果的风险比(RR)和率结果的发病率比(IRR)。当研究使用相同的连续测量时,我们估计平均差(MD);当使用不同测量或相同测量的不同格式时,我们估计标准化平均差(SMD)。在可能的情况下,我们进行了各种通常预先设定的敏感性和亚组分析。

主要结果

我们纳入了30项研究,这些研究评估了三维运动(太极拳和瑜伽)、平衡训练或力量与阻力训练。其中两项是整群随机试验,两项是交叉试验,一项是半随机试验。这些研究共纳入2878名参与者,平均年龄在68至85岁之间。大多数研究纳入的女性多于男性,有四项研究仅招募女性。十二项研究招募了跌倒风险增加的参与者;其中三项还招募了有跌倒恐惧的参与者。试验中分配方法的报告不佳,使得在大多数研究中难以评估选择偏倚的风险。所有研究在实施和检测偏倚方面风险都很高,因为参与者和结果评估者均未设盲,且结果为自我报告。十二项研究在失访偏倚方面风险很高。使用GRADE标准,我们判断干预后立即出现的跌倒恐惧的证据质量为“低”,短期或长期随访时的跌倒恐惧及所有其他结果的证据质量为“极低”。运动干预与干预后立即出现的跌倒恐惧有小到中度的降低相关(有利于运动的标准化平均差为0.37,95%置信区间(CI)为0.18至0.56;24项研究;1692名参与者,低质量证据)。用于测量跌倒恐惧的不同量表之间的合并效应量无显著差异。虽然没有一项敏感性分析改变效应方向,但效应量最大的降低是在剔除一项有73名参与者的极端离群值研究后(有利于运动的标准化平均差为0.24,95%CI为0.12至0.36)。我们的亚组分析均未提供有力证据表明在研究主要目的(减少跌倒恐惧或其他目的)、研究人群(基于跌倒风险增加与否进行招募)、研究运动干预特征或研究对照干预(无治疗或替代干预)方面存在效应差异。然而,有一些微弱证据表明与替代对照相比,运动的效应较小,包括无降低。有极低质量证据表明运动干预可能与干预后长达六个月(标准化平均差为0.17,95%CI为 -0.05至0.38;四项研究,356名参与者)和六个月以上(标准化平均差为0.20,95%CI为 -0.01至0.41;三项研究,386名参与者)的跌倒恐惧有小幅度降低相关。极低质量证据表明,这些研究中也报告了跌倒恐惧的运动干预降低了跌倒风险,跌倒风险的衡量方式为参与者在随访期间至少发生一次跌倒或随访期间的跌倒次数。四项研究的极低质量证据表明,运动干预似乎并未减轻抑郁症状或增加身体活动。唯一一项报告运动干预对焦虑影响的研究发现两组之间无差异。没有研究报告运动干预对活动回避或成本的影响。重要的是要记住,我们纳入的研究并不代表运动干预对跌倒、抑郁、焦虑或身体活动影响的全部证据,因为我们的综述仅包括报告了跌倒恐惧的研究。

作者结论

社区居住老年人的运动干预可能在干预后立即在一定程度上减轻跌倒恐惧,而不会增加跌倒风险或频率。没有足够的证据来确定运动干预在干预结束后是否能减轻跌倒恐惧或其对其他结果的影响。虽然需要来自精心设计的随机试验的进一步证据,但应优先建立一套核心结果指标,包括所有研究社区居住老年人运动干预效果的试验中的跌倒恐惧。

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