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乳腺癌的社会心理/生存问题:我们做得更好了吗?

Psychosocial/survivorship issues in breast cancer: are we doing better?

机构信息

Sussex Health Outcomes Research and Education in Cancer (SHORE-C), Brighton and Sussex Medical School, University of Sussex, Falmer, East Sussex, UK.

出版信息

J Natl Cancer Inst. 2014 Nov 27;107(1):335. doi: 10.1093/jnci/dju335. Print 2015 Jan.

Abstract

Modern breast cancer treatment offers many women greater prospects of cure or lengthier, good quality survival than was possible in the past. Advances include improved diagnostic and staging procedures, sophisticated onco-plastic surgery, enhanced radiotherapy techniques, and targeted systemic therapies. Much more attention has also been paid to cancer care delivery and access to specialist nurses, counsellors, support groups, and services provided by breast cancer charities. However, there are some concerns that these considerable improvements in treatment delivery and clinical outcomes have not led to similar benefits in the psychosocial, functional, and sexual well-being of women. The impact that non-life threatening, long-term iatrogenic harms of otherwise efficacious anticancer treatments has on patients is often overlooked; this is in part because of the emphasis given to physician-reported safety data in trials and the general exclusion of patient-reported outcomes (PROs). A failure to utilise reliable PRO measures has meant that some problems are underreported, which consequently has hampered much-needed research into ameliorative interventions. Systematic monitoring of quality of life-threatening side effects would permit early implementation of effective interventions and enhance long-term survivorship. Some examples of the pervasive difficulties that continue to affect survivors and evidence that certain interventions might help are provided in this commentary.

摘要

现代乳腺癌治疗为许多女性提供了比过去更大的治愈机会或更长时间、更高质量的生存机会。这些进步包括改进的诊断和分期程序、复杂的肿瘤整形手术、增强的放疗技术以及靶向系统治疗。此外,人们更加关注癌症护理的提供以及获得专科护士、咨询师、支持小组和乳腺癌慈善机构提供的服务的机会。然而,有人担心,在治疗提供和临床结果方面的这些显著改善并没有给女性的社会心理、功能和性健康带来类似的好处。非威胁生命的、长期医源性的抗癌治疗的副作用对患者的影响往往被忽视;这在一定程度上是因为试验中强调了医生报告的安全性数据,并且通常排除了患者报告的结果 (PROs)。未能使用可靠的 PRO 措施意味着一些问题报告不足,这反过来又阻碍了对缓解干预措施的急需研究。对危及生命的生活质量副作用的系统监测将允许早期实施有效的干预措施,并提高长期生存能力。本评论提供了一些仍在影响幸存者的普遍困难的例子,并提供了一些证据表明某些干预措施可能有所帮助。

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