Goto S, Hirano A, Rojas-Corona R R
Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467.
Ann Neurol. 1989 Mar;25(3):298-304. doi: 10.1002/ana.410250315.
The neostriatum of 7 autopsied patients with Huntington's disease (HD) was examined immunohistochemically using purified antibody against calcineurin, which may be present only in the medium-size spinous neurons of the mammalian striatum. This study revealed a marked loss of calcineurin-positive cells in the caudate nucleus and the putamen in all HD patients, compared with control subjects, and there was some variation among the HD patients. Four HD patients showed significantly lower density of calcineurin-positive cells in the caudate nucleus than in the putamen. The remaining calcineurin-positive cells in the caudate nucleus and the putamen had a mosaic-like pattern, demonstrating a subregional difference in distribution. This finding suggests that there are subregional as well as compartmental differences in the vulnerability of the calcineurin-positive cells in the striatum of patients with HD.
利用针对钙调神经磷酸酶的纯化抗体，对7例亨廷顿舞蹈病（HD）尸检患者的新纹状体进行了免疫组织化学检查，该抗体可能仅存在于哺乳动物纹状体的中等大小棘状神经元中。本研究显示，与对照受试者相比，所有HD患者的尾状核和壳核中钙调神经磷酸酶阳性细胞均显著减少，且HD患者之间存在一定差异。4例HD患者尾状核中钙调神经磷酸酶阳性细胞密度显著低于壳核。尾状核和壳核中剩余的钙调神经磷酸酶阳性细胞呈镶嵌样模式，表明分布存在亚区域差异。这一发现提示，HD患者纹状体中钙调神经磷酸酶阳性细胞的易损性存在亚区域以及分区差异。
