Oyanagi K, Ikuta F
Clin Neuropathol. 1987 Mar-Apr;6(2):71-9.
In order to reevaluate the quantitative changes in the neostriatum of Huntington's chorea (HC), sections of the caudate head and putamen from 4 HC and 5 control cases were treated with Klüver-Barrera stain and the nuclear area of the neurons was measured by a digitizer. The number of neurons of different sizes was evaluated statistically. This study revealed a significant decrease in the number of large neurons (nuclear area; greater than 121 microns 2) as well as a severe decrease in the number of small neurons (nuclear area; less than 80 microns 2) in the neostriatum of HC. There was a parallel degree of neuronal loss in the upper and lower portions of both caudate head and putamen. The degree of neuronal loss was slightly more severe in the putamen than in the caudate head. The depletion of the large neurons was not correlated with the loss of small neurons. The number of medium-sized neurons (nuclear area; 81-120 microns 2) showed no statistically significant change.
为了重新评估亨廷顿舞蹈症（HC）新纹状体的定量变化，对4例HC患者和5例对照者的尾状核头部和壳核切片进行Klüver-Barrera染色，并用数字转换器测量神经元的核面积。对不同大小神经元的数量进行统计学评估。本研究显示，HC患者新纹状体中大型神经元（核面积大于121平方微米）的数量显著减少，小型神经元（核面积小于80平方微米）的数量也严重减少。在尾状核头部和壳核的上部和下部，神经元丢失的程度相当。壳核中神经元丢失的程度略比尾状核头部严重。大型神经元的减少与小型神经元的丢失无关。中型神经元（核面积81-120平方微米）的数量没有统计学上的显著变化。
