犰狳作为麻风分枝杆菌的动物模型和储存宿主。

The armadillo as an animal model and reservoir host for Mycobacterium leprae.

作者信息

Balamayooran Gayathriy, Pena Maria, Sharma Rahul, Truman Richard W

机构信息

Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana; Department of Health Human Services, Health Resources and Services Administration, National Hansen's Disease Program, Baton Rouge, Louisiana.

Department of Health Human Services, Health Resources and Services Administration, National Hansen's Disease Program, Baton Rouge, Louisiana.

出版信息

Clin Dermatol. 2015 Jan-Feb;33(1):108-15. doi: 10.1016/j.clindermatol.2014.07.001.

DOI:10.1016/j.clindermatol.2014.07.001

PMID:25432816

Abstract

Apart from humans, armadillos are the only known natural hosts of Mycobacterium leprae. They are well developed as hosts for in vivo propagation of M leprae and are advancing as models for studying the pathogenesis of leprosy and translational research. Armadillos are immunologically intact. They exhibit the full Ridley-Jopling spectrum of histopathologic responses to M leprae and uniquely manifest extensive neurological involvement that closely recapitulates human leprosy. In addition, free-ranging armadillos in some regions are known to harbor a naturally occurring infection with M leprae, and zoonotic transmission between armadillos and humans has been implicated in a large number of new case presentations. We review the role of the armadillo as a model for leprosy and reservoir for human infection.

摘要

除人类外，犰狳是已知的麻风分枝杆菌唯一自然宿主。它们作为麻风分枝杆菌体内繁殖的宿主发育良好，正逐渐成为研究麻风病发病机制和转化研究的模型。犰狳的免疫系统完整。它们对麻风分枝杆菌表现出完整的里德利 - 乔普林组织病理学反应谱，并且独特地表现出广泛的神经受累，这与人类麻风病极为相似。此外，已知在某些地区自由放养的犰狳自然感染了麻风分枝杆菌，犰狳与人类之间的人畜共患病传播已被认为与大量新病例的出现有关。我们综述了犰狳作为麻风病模型和人类感染源的作用。