Kim S J, Jung J K, Kang B C, Bae S N
Catholic University Medical College, Seoul, Korea.
Gan To Kagaku Ryoho. 1989 Apr;16(4 Pt 2-3):1561-7.
In summary of our 15 years experiences it is obvious that at least about 15% of GTT patients still do not get complete remission in spite of development of multiagent chemotherapy. To obtain better therapeutical result in unceasing problems should be solved and the improvement in newer methods of management as listed below is mandatory: (1) Prediction on risk factors and early diagnosis of the persistent GTT before and after molar evacuation (2) "Clinico-biochemical classification" based on more collective tumor markers (3) New chemotherapeutic agents (4) Regimen for prevention and/or modulation of drug resistance (5) Multimodality treatment including initial and adjuvant surgery, irradiation and immune response modifiers. (6) Remission consolidation
总结我们15年的经验，很明显，尽管多药化疗有所发展，但至少约15%的妊娠滋养细胞肿瘤（GTT）患者仍未完全缓解。为了在不断出现的问题中获得更好的治疗效果，必须解决以下问题并改进如下列出的新管理方法：（1）葡萄胎排空前后对持续性GTT危险因素的预测和早期诊断；（2）基于更多肿瘤标志物的“临床生化分类”；（3）新的化疗药物；（4）预防和/或调节耐药性的方案；（5）包括初始和辅助手术、放疗和免疫反应调节剂的多模式治疗；（6）缓解巩固
