Westerhout F C
Calif Med. 1966 Mar;104(3):179-83.
Trophoblastic tumors are a notoriously unpredictable group in which metastasis may occur from histologically benign tumors and cause death, whereas a histologically malignant tumor may spontaneously disappear. Additional problems are created by the inability to accurately establish a diagnosis before abortion of molar tissue or development of metastasis.In recent years chemotherapy has dramatically improved the prognosis of patients with choriocarcinoma. This fact, plus the importance of the time interval between onset of disease and the beginning of chemotherapy, makes close follow-up of patients with trophoblastic tumors imperative.Concepts of therapy for trophoblastic tumors are rapidly changing. Indications for chemotherapy are broadening, especially in the areas of persistent and metastatic trophoblastic disease. As surgical intervention in the form of hysterectomy is becoming less important, the reproductive capacity of these young women is being preserved. Astute diagnosis, appropriate therapy and active life-long follow-up are the essentials in the management of patients with trophoblastic disease.
滋养细胞肿瘤是一类众所周知的难以预测的肿瘤，组织学上良性的肿瘤可能发生转移并导致死亡，而组织学上恶性的肿瘤可能会自发消失。在流产葡萄胎组织或发生转移之前，无法准确做出诊断会带来更多问题。近年来，化疗显著改善了绒毛膜癌患者的预后。这一事实，再加上疾病发作与开始化疗之间时间间隔的重要性，使得对滋养细胞肿瘤患者进行密切随访势在必行。滋养细胞肿瘤的治疗观念正在迅速变化。化疗的适应证正在扩大，尤其是在持续性和转移性滋养细胞疾病领域。随着子宫切除术形式的手术干预变得不那么重要，这些年轻女性的生育能力得到了保留。敏锐的诊断、恰当的治疗以及积极的终身随访是滋养细胞疾病患者管理的关键要素。
