Pajic-Lijakovic Ivana
Faculty of Technology and Metallurgy, Belgrade University, Karnegijeva 4, 11 000 Belgrade, Serbia.
Prog Biophys Mol Biol. 2015 Jan;117(1):113-24. doi: 10.1016/j.pbiomolbio.2014.11.003. Epub 2014 Nov 27.
Various modeling approaches have been applied to describe structural changes of the erythrocyte constituents under osmotic stress. The constituents: (1) the lipid bilayer, (2) the actin-spectrin cortex, (3) the trans-membrane protein band 3, (4) the intracellular hemoglobin contribute to the relaxation phenomenon. Cells response includes the successive sub-bioprocesses: (1) erythrocyte swelling, (2) lifetime of the lipid structural integrity and the rearrangements of trans-membrane protein band 3, (3) the reversible hemolytic hole formation and hemoglobin release to surrounding solution. Herein, an attempt is made to discuss and connect various modeling approaches on various time scales which have been proposed in the literature in order to shed further light to this complex phenomenon which induces the erythrocyte to ghost phase transition. The results indicate that the erythrocyte swelling rate represents the key control factor for the structural ordering of the cell parts which induces anomalous nature of energy dissipation.
已经应用了各种建模方法来描述渗透应激下红细胞成分的结构变化。这些成分包括：（1）脂质双层，（2）肌动蛋白-血影蛋白皮层，（3）跨膜蛋白带3，（4）细胞内血红蛋白，它们都对松弛现象有贡献。细胞反应包括连续的亚生物过程：（1）红细胞肿胀，（2）脂质结构完整性的维持时间以及跨膜蛋白带3的重排，（3）可逆性溶血孔的形成以及血红蛋白释放到周围溶液中。在此，我们尝试讨论并联系文献中提出的各种时间尺度上的建模方法，以便进一步阐明这种导致红细胞向空壳相转变的复杂现象。结果表明，红细胞肿胀率是诱导能量耗散异常性质的细胞各部分结构有序性的关键控制因素。
