Chemical Engineering, Indian Institute of Technology Gandhinagar, Chandkheda, Ahmedabad 382424, Gujarat, India.
Chemical Engineering, Indian Institute of Technology Gandhinagar, Chandkheda, Ahmedabad 382424, Gujarat, India.
Ultrason Sonochem. 2015 May;24:114-22. doi: 10.1016/j.ultsonch.2014.11.016. Epub 2014 Nov 18.
Nucleation kinetics of liquid antisolvent precipitation of a poorly water soluble drug curcumin in presence of ultrasound and surfactants have been estimated. Ultrasound and stabilizers were found to have opposing effects on induction time (τ ind), metastable zone width (MSZW) and nucleation rates (J) of curcumin during antisolvent precipitation. The use of ultrasound (in presence or absence of stabilizers) was found to decrease τ ind and MSZW drastically while the values of nucleation rates were found to increase. In contrast to these observations, use of stabilizers (in presence or absence of ultrasound) were found to increase MSZW, increase τ ind and lower the nucleation rates (J) of curcumin. The solid-liquid interfacial energies (γSL) for curcumin in aqueous ethanolic solutions (with and without stabilizers) have also been calculated using experimentally estimated induction time (τ ind) and supersaturation data. The values of solid-liquid interfacial energies were found to be in the range of 1.5-3.5 mJ/m(2). In comparison to these values, the values of γSL predicted by Mersmann equation and equation proposed by Bennema and Sohnel were found to be significantly higher and were in the range of 10-30 mJ/m(2).
在超声和表面活性剂存在的条件下，研究了难溶于水的药物姜黄素的抗溶剂沉淀过程中的成核动力学。研究发现，在抗溶剂沉淀过程中，超声和稳定剂对姜黄素的诱导时间（τ ind）、亚稳区宽度（MSZW）和成核速率（J）有相反的影响。使用超声（无论是否存在稳定剂）都会大大降低τ ind和 MSZW，而成核速率（J）的值则会增加。与这些观察结果相反，使用稳定剂（无论是否存在超声）会增加 MSZW、增加τ ind 并降低姜黄素的成核速率（J）。还使用实验估计的诱导时间（τ ind）和过饱和度数据计算了姜黄素在水醇溶液（有和没有稳定剂）中的固液界面能（γ SL）。发现固液界面能的值在 1.5-3.5 mJ/m 2 之间。与这些值相比，Mersmann 方程和 Bennema 和 Sohnel 提出的方程预测的γ SL 值要高得多，范围在 10-30 mJ/m 2 之间。
