Hazi Mastan T, Lenka Maheswata, Sarkar Debasis
Department of Chemical Engineering, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Department of Chemical Engineering, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Ultrason Sonochem. 2017 May;36:497-506. doi: 10.1016/j.ultsonch.2016.12.017. Epub 2016 Dec 19.
This study investigates the effect of ultrasound on metastable zone width (MSZW) during crystallization of l-phenylalanine from aqueous solution. The solubility of l-phenylalanine in water was measured gravimetrically in the temperature range of 293.15-333.15K. The MSZW was measured by conventional polythermal method for four different cooling rates at five different saturation temperatures in absence and presence of ultrasound. The MSZW increased with increase in cooling rates and decreased with increase in saturation temperature. The application of ultrasound considerably reduced the MSZW for all the experiments. The obtained MSZW data are analysed using four different approaches to calculate various nucleation parameters. In presence of ultrasound, the apparent nucleation order decreased and nucleation rate constant increased significantly.
本研究考察了超声对L-苯丙氨酸从水溶液中结晶过程中亚稳区宽度（MSZW）的影响。采用重量法在293.15 - 333.15K温度范围内测定了L-苯丙氨酸在水中的溶解度。在有无超声的情况下，通过传统的变温法在五个不同的饱和温度下对四种不同的冷却速率测量了亚稳区宽度。亚稳区宽度随冷却速率的增加而增大，随饱和温度的升高而减小。在所有实验中，超声的应用显著降低了亚稳区宽度。使用四种不同方法分析所获得的亚稳区宽度数据，以计算各种成核参数。在有超声的情况下，表观成核级数降低，成核速率常数显著增加。
