微小RNA-26a通过靶向三阴性乳腺癌中的黏附素抑制肿瘤增殖和转移。
miR-26a suppresses tumour proliferation and metastasis by targeting metadherin in triple negative breast cancer.
作者信息
Liu Peng, Tang Hailin, Chen Bo, He Zhimin, Deng Min, Wu Minqing, Liu Xiaoping, Yang Lu, Ye Feng, Xie Xiaoming
机构信息
Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.
Cancer Hospital and Cancer Research Institute, Guangzhou Medical University, Guangzhou, China.
出版信息
Cancer Lett. 2015 Feb 1;357(1):384-392. doi: 10.1016/j.canlet.2014.11.050. Epub 2014 Nov 27.
It has been reported that miR-26a plays an important role in various cancers. In this study, we found that miR-26a was downregulated in triple-negative breast cancer (TNBC), and its expression levels were associated with lymph node metastasis and overall survival in TNBC. We also found that the ectopic expression of miR-26a inhibited TNBC cell proliferation and metastasis in vitro and in vivo by downregulating MTDH (a miR-26a' target gene) mRNA and protein and that the overexpression of MTDH could partially abrogate miR-26a-mediated suppression. Our data suggest that miR-26a functions as a tumour suppressor in TNBC development and serves as a prognostic marker for breast cancer.
据报道，miR-26a在多种癌症中发挥重要作用。在本研究中，我们发现miR-26a在三阴性乳腺癌（TNBC）中表达下调，其表达水平与TNBC的淋巴结转移及总生存期相关。我们还发现，miR-26a的异位表达通过下调MTDH（miR-26a的一个靶基因）的mRNA和蛋白水平，在体外和体内抑制TNBC细胞的增殖和转移，并且MTDH的过表达可部分消除miR-26a介导的抑制作用。我们的数据表明，miR-26a在TNBC发生发展中起肿瘤抑制作用，并可作为乳腺癌的预后标志物。
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