Quraishi Roshni, Sanyal Somali, Dwivedi Medha, Moitra Monika, Dwivedi Manish
Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Gomtinagar Extension, Lucknow-226028, India.
Research Cell, Amity University Uttar Pradesh, Lucknow Campus, Gomtinagar Extension, Lucknow-226028, India.
Curr Drug Targets. 2024;25(6):375-387. doi: 10.2174/0113894501182288240319074330.
Gallbladder cancer (GBC) is an uncommon condition in which malignant (cancer) cells are detected in gallbladder tissue. Cancer is often triggered when normal cells turn malignant and begin to spread. Cancer can also be caused by genetic anomalies that result in uncontrolled cell proliferation and tumor development. MicroRNAs (also known as miRNAs or miRs) are a group of small, endogenous, non-coding RNAs of 19-23 nucleotides in length, which play a key role in post-transcriptional gene regulation. These miRNAs serve as negative gene regulators by supervising target genes and regulating biological processes, including cell proliferation, migration, invasion, and apoptosis. Cancer development and progression relate to aberrant miRNA expression. This review demonstrated the implication of various genetic factors and microRNAs in developing and regulating GBC. This suggests the potential of genes and RNAs as the diagnostic, prognostic, and therapeutic targets in gallbladder cancer.
胆囊癌（GBC）是一种罕见病症，其中在胆囊组织中检测到恶性（癌）细胞。癌症通常在正常细胞转变为恶性并开始扩散时引发。癌症也可能由导致细胞不受控制地增殖和肿瘤发展的基因异常引起。微小RNA（也称为miRNA或miR）是一组长度为19 - 23个核苷酸的小的内源性非编码RNA，其在转录后基因调控中起关键作用。这些微小RNA通过监督靶基因并调节包括细胞增殖、迁移、侵袭和凋亡在内的生物学过程，作为负性基因调节因子发挥作用。癌症的发生和发展与异常的微小RNA表达有关。本综述阐述了各种遗传因素和微小RNA在胆囊癌发生和调控中的作用。这表明基因和RNA作为胆囊癌诊断、预后和治疗靶点的潜力。
