Gibbons Linda, Rollinson Sara, Thompson Jennifer C, Robinson Andrew, Davidson Yvonne S, Richardson Anna, Neary David, Pickering-Brown Stuart M, Snowden Julie S, Mann David M A
Faculty of Human and Medical Sciences, Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK.
Faculty of Human and Medical Sciences, Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK; Cerebral Function Unit, Department of Neurology, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, Salford, UK.
Neurobiol Aging. 2015 Mar;36(3):1603.e1-4. doi: 10.1016/j.neurobiolaging.2014.10.023. Epub 2014 Oct 18.
We have measured plasma progranulin and interleukin-6 in 230 patients with frontotemporal lobar degeneration (FTLD), 104 patients with Alzheimer's disease, and 161 control subjects. We have replicated previous findings of decreased levels of progranulin protein in FTLD because of mutations in GRN and show this is not observed in FTLD cases because of other causes. interleukin-6 levels were increased in FTLD overall, but these did not discriminate between clinical and genetic subtypes.
我们检测了230例额颞叶痴呆（FTLD）患者、104例阿尔茨海默病患者和161名对照者的血浆前颗粒蛋白和白细胞介素-6。我们重复了之前关于FTLD中由于GRN基因突变导致前颗粒蛋白水平降低的研究结果，并表明在由其他原因引起的FTLD病例中未观察到这种情况。总体而言，FTLD患者的白细胞介素-6水平升高，但这些水平在临床和基因亚型之间并无差异。
