Quan Ke, Huang Jin, Yang Xiaohai, Yang Yanjing, Ying Le, Wang He, He Yong, Wang Kemin
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China.
Chem Commun (Camb). 2015 Jan 18;51(5):937-40. doi: 10.1039/c4cc08488h.
Here we introduce an enzyme-free and colorimetric detection strategy for small molecule adenosine. The approach is based on the adenosine-aptamer binding triggered liberation of an initiator strand that consecutively catalyzes DNA hairpins hybridized from singles to couples. These couples induce gold nanoparticles assembled via crosslinking, which could be visualized by a color change.
在此，我们介绍一种用于小分子腺苷的无酶比色检测策略。该方法基于腺苷适配体结合引发的引发链释放，引发链连续催化从单链杂交成双链的DNA发夹结构。这些双链通过交联诱导金纳米颗粒组装，可通过颜色变化观察到。
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