Milovancev M, Hauck M, Keller C, Stranahan L W, Mansoor A, Malarkey D E
Department of Clinical Sciences, Oregon State University, Corvallis, Oregon, USA.
Department of Clinical Sciences, North Carolina State University, Raleigh, North Carolina, USA.
J Comp Pathol. 2015 Jan;152(1):22-7. doi: 10.1016/j.jcpa.2014.09.005. Epub 2014 Nov 27.
Comparative analyses of canine and human soft tissue sarcomas (STSs) are lacking. This study compared the histological and immunohistochemical (labelling for desmin, smooth muscle actin [SMA], CD31, pancytokeratin, S100 and CD34) appearance of 32 archived, formalin-fixed, paraffin wax-embedded canine STS tumour specimens by board-certified veterinary and medical pathologists, both blinded to the other's interpretations. Comparison between the veterinary and human diagnoses revealed a generally consistent pattern of interpretation with few notable variations. Most tumours (13/32) were judged to display similar histomorphological appearance to human low-grade spindle cell sarcomas, appearing non-distinctive and morphologically of a fibroblastic/myofibroblastic type. Five canine cases resembled human liposarcoma, but with atypical desmin-positive epithelioid cells present. Five canine cases resembled human spindle cell sarcoma with myxoid features and two additional cases resembled human myxofibrosarcoma. Seven canine cases were noted to resemble human undifferentiated sarcoma. Findings in the present study demonstrate that canine STSs display histological and immunohistochemical features similar to their human equivalents. Because of these cross-species similarities, a particular opportunity exists to understand the biology and treatment of human STS by potentially including dogs as clinical models.
目前尚缺乏对犬类和人类软组织肉瘤（STS）的比较分析。本研究由获得委员会认证的兽医病理学家和医学病理学家，对32份存档的、经福尔马林固定、石蜡包埋的犬类STS肿瘤标本的组织学和免疫组织化学（标记结蛋白、平滑肌肌动蛋白[SMA]、CD31、全细胞角蛋白、S100和CD34）表现进行了比较，双方对彼此的解读均不知情。兽医诊断与人类诊断之间的比较显示，总体上解读模式一致，仅有少数显著差异。大多数肿瘤（13/32）被判定与人类低级别梭形细胞肉瘤具有相似的组织形态学表现，外观无明显特征，形态上为成纤维细胞/肌成纤维细胞类型。5例犬类病例类似于人类脂肪肉瘤，但存在非典型的结蛋白阳性上皮样细胞。5例犬类病例类似于具有黏液样特征的人类梭形细胞肉瘤，另有2例类似于人类黏液纤维肉瘤。7例犬类病例被认为类似于人类未分化肉瘤。本研究结果表明，犬类STS具有与其人类对应物相似的组织学和免疫组织化学特征。由于这些跨物种的相似性，通过将犬类作为临床模型，有可能为了解人类STS的生物学特性和治疗方法提供特殊的机会。
