• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

比较病理学委员会促进了犬类和人类癌症患者之间知识的转化。

Comparative pathology boards facilitate the translation of knowledge between canine and human cancer patients.

作者信息

Beck Jessica A, Mazcko Christina, Belluco Sara, Bitar Mireille, Brat Daniel, Bush Jonathan W, Chkheidze Rati, Corps Kara N, Frank Chad, Giannini Caterina, Horbinski Craig, Huse Jason T, Koehler Jennifer W, Miller Andrew D, Miller C Ryan, O'Sullivan M Gerard, Phillips Joanna J, Rissi Daniel R, Schott Courtney R, Stemmer-Rachamimov Anat, Yip Stephen, LeBlanc Amy K

机构信息

Comparative Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Université de Lyon, VetAgro Sup, UPSP 2021.A104 ICE 'Interactions Cellules Environnement', Axe Cancérologie, Lyon, France.

出版信息

Brain Pathol. 2025 Sep;35(5):e70013. doi: 10.1111/bpa.70013. Epub 2025 May 5.

DOI:10.1111/bpa.70013
PMID:40325876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12352920/
Abstract

Comparative pathology boards bring together anatomic pathologists with expertise in canine and human histology to identify shared features, including immune or TME components, tumor subtypes, or prognostic tissue biomarkers. This article summarizes feedback to improve future initiatives and enhance the translational relevance of comparative oncology for human patients.

摘要

比较病理学委员会汇聚了在犬类和人类组织学方面具有专业知识的解剖病理学家，以识别共同特征，包括免疫或肿瘤微环境成分、肿瘤亚型或预后组织生物标志物。本文总结了相关反馈，以改进未来的举措，并增强比较肿瘤学对人类患者的转化相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bda7/12352920/f63412843c73/BPA-35-e70013-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bda7/12352920/4a3d276374d7/BPA-35-e70013-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bda7/12352920/f63412843c73/BPA-35-e70013-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bda7/12352920/4a3d276374d7/BPA-35-e70013-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bda7/12352920/f63412843c73/BPA-35-e70013-g002.jpg

相似文献

1
Comparative pathology boards facilitate the translation of knowledge between canine and human cancer patients.比较病理学委员会促进了犬类和人类癌症患者之间知识的转化。
Brain Pathol. 2025 Sep;35(5):e70013. doi: 10.1111/bpa.70013. Epub 2025 May 5.
2
Variation within and between digital pathology and light microscopy for the diagnosis of histopathology slides: blinded crossover comparison study.数字病理学与光学显微镜检查在组织病理学切片诊断中的内部及相互间差异：双盲交叉对比研究
Health Technol Assess. 2025 Jul;29(30):1-75. doi: 10.3310/SPLK4325.
3
Tumor-Associated Macrophages and Collagen Remodeling in Mammary Carcinomas: A Comparative Analysis in Dogs and Humans.犬类和人类乳腺癌中肿瘤相关巨噬细胞与胶原重塑的比较分析
Int J Mol Sci. 2025 Jul 18;26(14):6928. doi: 10.3390/ijms26146928.
4
The Role of Canine Models of Human Cancer: Overcoming Drug Resistance Through a Transdisciplinary "One Health, One Medicine" Approach.人类癌症犬类模型的作用：通过跨学科的“同一健康，同一医学”方法克服耐药性。
Cancers (Basel). 2025 Jun 17;17(12):2025. doi: 10.3390/cancers17122025.
5
Assessing the Quality of Rectal Cancer Pathology Reports in National Surgical Adjuvant Breast and Bowel Project Protocol R-04/NRG Oncology.评估国家外科辅助乳腺和肠道项目协议 R-04/NRG 肿瘤学中直肠癌病理报告的质量。
Dis Colon Rectum. 2020 Aug;63(8):1063-1070. doi: 10.1097/DCR.0000000000001578.
6
Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in canine tumors.有丝分裂活性：犬肿瘤评估方法学和预后价值的系统文献回顾。
Vet Pathol. 2024 Sep;61(5):752-764. doi: 10.1177/03009858241239565. Epub 2024 Mar 27.
7
Diagnosis and Classification of Primary Nodal Lymphomas in Dogs: A Consensus of the Oncology-Pathology Working Group.犬原发性淋巴结淋巴瘤的诊断与分类：肿瘤病理学工作组共识
Vet Comp Oncol. 2025 Sep;23(3):331-345. doi: 10.1111/vco.13064. Epub 2025 May 19.
8
Interplay between tumor mutation burden and the tumor microenvironment predicts the prognosis of pan-cancer anti-PD-1/PD-L1 therapy.肿瘤突变负荷与肿瘤微环境之间的相互作用可预测泛癌抗PD-1/PD-L1治疗的预后。
Front Immunol. 2025 Jul 24;16:1557461. doi: 10.3389/fimmu.2025.1557461. eCollection 2025.
9
Pleomorphic Lobular Carcinoma of the Mammary Gland in Women and Female Dogs: A Comparative Clinical-Pathological and Immunophenotypic Analysis.女性和雌性犬乳腺多形性小叶癌：一项比较临床病理及免疫表型分析
Vet Sci. 2025 Jun 14;12(6):587. doi: 10.3390/vetsci12060587.
10
Improved characterization and translation of NK cells for canine immunotherapy.用于犬类免疫治疗的自然杀伤细胞的特征改进与转化
Front Vet Sci. 2024 Feb 6;11:1336158. doi: 10.3389/fvets.2024.1336158. eCollection 2024.

本文引用的文献

1
Aggressive human MenG C meningiomas have a molecular counterpart in canines.侵袭性人类脑脊膜瘤在犬类中有分子对应物。
Acta Neuropathol. 2024 Feb 20;147(1):42. doi: 10.1007/s00401-024-02692-3.
2
Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas.犬脑膜瘤由3个DNA甲基化组构成，这些甲基化组类似于人类脑膜瘤的分子特征。
Acta Neuropathol. 2024 Feb 20;147(1):43. doi: 10.1007/s00401-024-02693-2.
3
Review of Histological Grading Systems in Veterinary Medicine.兽医组织学分级系统综述。
Vet Pathol. 2021 Sep;58(5):809-828. doi: 10.1177/0300985821999831. Epub 2021 Mar 26.
4
Mitotic Figures-Normal, Atypical, and Imposters: A Guide to Identification.有丝分裂图像——正常、非典型及伪装者：识别指南
Vet Pathol. 2021 Mar;58(2):243-257. doi: 10.1177/0300985820980049. Epub 2020 Dec 29.
5
A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma.犬神经胶质瘤修订诊断分类：旨在验证犬神经胶质瘤患者是否为人类神经胶质瘤的天然临床前模型。
J Neuropathol Exp Neurol. 2018 Nov 1;77(11):1039-1054. doi: 10.1093/jnen/nly085.
6
The dog as an animal model for bladder and urethral urothelial carcinoma: Comparative epidemiology and histology.狗作为膀胱和尿道尿路上皮癌的动物模型：比较流行病学和组织学
Oncol Lett. 2018 Aug;16(2):1641-1649. doi: 10.3892/ol.2018.8837. Epub 2018 May 30.
7
Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients.创建美国国立癌症研究所比较脑肿瘤联盟：为从犬类脑肿瘤患者到人类脑肿瘤患者的新知识转化提供信息。
Neuro Oncol. 2016 Sep;18(9):1209-18. doi: 10.1093/neuonc/now051. Epub 2016 May 14.
8
Comparative pathology of canine soft tissue sarcomas: possible models of human non-rhabdomyosarcoma soft tissue sarcomas.犬软组织肉瘤的比较病理学：人类非横纹肌肉瘤软组织肉瘤的可能模型
J Comp Pathol. 2015 Jan;152(1):22-7. doi: 10.1016/j.jcpa.2014.09.005. Epub 2014 Nov 27.
9
Canine osteosarcoma: a naturally occurring disease to inform pediatric oncology.犬骨肉瘤：一种用于为儿科肿瘤学提供信息的自然发生的疾病。
ILAR J. 2014;55(1):69-85. doi: 10.1093/ilar/ilu009.
10
Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.犬类散发性自然发生的黑色素瘤作为人类黑色素瘤的临床前模型。
Pigment Cell Melanoma Res. 2014 Jan;27(1):37-47. doi: 10.1111/pcmr.12185. Epub 2013 Nov 21.