Sharma Aditya M, Norton Patrick T, Zhu Daisy
Division of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia.
Department of Radiology, University of Virginia, Charlottesville, Virginia.
Semin Intervent Radiol. 2014 Dec;31(4):281-91. doi: 10.1055/s-0034-1393963.
Peripheral artery disease (PAD) is estimated to affect more than 20% of people older than 65 years. The vast majority of patients with symptoms suggestive of PAD have atherosclerosis often associated with conventional vascular risk factors such as smoking, diabetes, dyslipidemia, and inflammation. A minority of people presenting with symptoms suggesting PAD have an alternative etiology. These groups of disorders are often underdiagnosed, and if diagnosed correctly the diagnosis may be delayed. Understanding these pathologies well is important, as they can be very debilitating and optimal treatment may vary significantly. Inappropriate treatment of these disorders can lead to worsening morbidity and mortality. This article discusses the underlying causes of nonatherosclerotic PAD, including the diagnosis and treatment of these disorders.
据估计，外周动脉疾病（PAD）影响着超过20%的65岁以上人群。绝大多数有PAD症状的患者患有动脉粥样硬化，常伴有吸烟、糖尿病、血脂异常和炎症等传统血管危险因素。少数有PAD症状的人有其他病因。这些疾病群体常常诊断不足，如果诊断正确，诊断也可能会延迟。充分了解这些病理情况很重要，因为它们可能非常使人衰弱，而且最佳治疗方法可能有很大差异。对这些疾病的不当治疗会导致发病率和死亡率上升。本文讨论非动脉粥样硬化性PAD的潜在病因，包括这些疾病的诊断和治疗。
