Sanada Yukihiro, Urahashi Taizen, Ihara Yoshiyuki, Wakiya Taiichi, Okada Noriki, Yamada Naoya, Hirata Yuta, Mizuta Koichi
Hepatogastroenterology. 2014 Jul-Aug;61(133):1368-73.
BACKGROUND/AIMS: β-D glucan in the portal vein blood is processed by the hepatic reticuloendothelial system, and therefore, it is possible that the β-D glucan kinetics of the peripheral vein blood may be useful as a biological index. In this study, the β-D glucan levels in the peripheral and portal vein blood during liver transplantation were measured in order to study the clinical significance of the molecule.
The subjects comprised 20 patients who underwent living donor liver transplantation. In the perioperative period, the β-D glucan levels were measured before liver transplantation, during surgical procedure, then on postoperative days 5, 14 and 21.
The portal vein blood showed a significantly higher level of β-D glucan than the peripheral blood (p<0.001). A significant difference of β-D glucan levels was observed between the pre-liver transplantation and postoperative days 5 (p=0.048). There was a significant positive correlation between the preoperative β-D glucan level and the period of postoperative hospitalization (p<0.001). The patients with fungal infections (35.0%) had a significantly longer period of hospitalization (p=0.019).
The β-D glucan kinetics accurately reflects the liver function and fungal infections. The β-D glucan level before liver transplantation can be used to
背景/目的：门静脉血中的β-D葡聚糖由肝网状内皮系统处理，因此，外周静脉血的β-D葡聚糖动力学有可能作为一种生物学指标。在本研究中，测量肝移植期间外周血和门静脉血中的β-D葡聚糖水平，以研究该分子的临床意义。
研究对象包括20例行活体肝移植的患者。在围手术期，于肝移植前、手术过程中、术后第5天、第14天和第21天测量β-D葡聚糖水平。
门静脉血中β-D葡聚糖水平显著高于外周血（p<0.001）。肝移植前与术后第5天的β-D葡聚糖水平存在显著差异（p=0.048）。术前β-D葡聚糖水平与术后住院时间呈显著正相关（p<0.001）。发生真菌感染的患者（35.0%）住院时间显著更长（p=0.019）。
β-D葡聚糖动力学准确反映肝功能和真菌感染。肝移植前的β-D葡聚糖水平可用于
