Simmons Kimber, Michels Aaron W
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, 1775 Aurora Court, Aurora, CO 80045, USA.
Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, 1775 Aurora Court, Aurora, CO 80045, USA.
Rheum Dis Clin North Am. 2014 Nov;40(4):797-811. doi: 10.1016/j.rdc.2014.07.008. Epub 2014 Sep 2.
Type 1 diabetes (T1D) is a chronic autoimmune disorder resulting from immune-mediated destruction of insulin-producing beta cells within the pancreatic islets. Prediction of T1D is now possible, as having 2 or more islet autoantibodies confers a 100% risk of diabetes development. With the ability to predict disease development, clinical trials to prevent diabetes onset have been completed and are currently under way. This review focuses on the natural history, prediction, and prevention trials in T1D. We review the lessons learned from these attempts at preventing a chronic autoimmune disease and apply the paradigm from T1D prevention to other autoimmune disorders.
1型糖尿病（T1D）是一种慢性自身免疫性疾病，由免疫介导的胰岛内产生胰岛素的β细胞破坏所致。现在可以预测T1D，因为拥有2种或更多种胰岛自身抗体患糖尿病的风险为100%。随着能够预测疾病发展，预防糖尿病发病的临床试验已经完成且目前正在进行。本综述重点关注T1D的自然史、预测和预防试验。我们回顾了这些预防慢性自身免疫性疾病尝试中吸取的经验教训，并将T1D预防的模式应用于其他自身免疫性疾病。
