Hawasli Jennifer A, Hopping Jacob R, Hsueh Eddy C
Department of Surgery, Saint Louis University School of Medicine, St. Louis, MO, United States.
Department of Surgery, Saint Louis University School of Medicine, St. Louis, MO, United States.
Int J Surg Case Rep. 2014;5(12):1225-8. doi: 10.1016/j.ijscr.2014.11.013. Epub 2014 Nov 11.
Retroperitoneal sarcomas have rarely been reported to secrete insulin-growth factor II (IGF-II) and produce an enigmatic hypoglycemia. IGF-II-secreting sarcomas represent an extremely rare subset of soft tissue tumors, and reports are limited to a handful of cases.
The authors present the case of hypoglycemia due to an IGF-II-secreting retroperitoneal sarcoma that was successfully treated by complete surgical resection. This report describes the diagnosis and management of this rare syndrome with 1-year follow-up and a review of the literature.
Steroid and growth hormone therapies also have efficacy to treat this hypoglycemia in some patients. However, outcomes appear better if combined with surgical resection.
The findings of this case report and review of the literature support a primary role for complete tumor resection to address tumor-induced hypoglycemia.
据报道，腹膜后肉瘤很少分泌胰岛素样生长因子II（IGF-II）并导致难以解释的低血糖症。分泌IGF-II的肉瘤是软组织肿瘤中极为罕见的一个子集，相关报道仅限于少数病例。
作者报告了一例因分泌IGF-II的腹膜后肉瘤导致低血糖症的病例，该病例通过完整手术切除成功治愈。本报告描述了这种罕见综合征的诊断和治疗，并进行了1年的随访及文献复习。
类固醇和生长激素疗法对部分患者的低血糖症也有治疗效果。然而，如果与手术切除相结合，效果似乎更好。
本病例报告及文献复习的结果支持完整肿瘤切除在治疗肿瘤诱导性低血糖症中起主要作用。
