用于1,1-二取代芳基烯烃不对称硼氢化反应的亚氨基吡啶恶唑啉铁催化剂。
Iminopyridine oxazoline iron catalyst for asymmetric hydroboration of 1,1-disubtituted aryl alkenes.
作者信息
Chen Jianhui, Xi Tuo, Lu Zhan
机构信息
Department of Chemistry, Zhejiang University , Hangzhou 310027, China.
出版信息
Org Lett. 2014 Dec 19;16(24):6452-5. doi: 10.1021/ol503282r. Epub 2014 Dec 1.
The highly regio- and enantioselective iron-catalyzed anti-Markovnikov hydroboration of 1,1-disubstituted aryl alkenes is reported by using a novel chiral iminopyridine oxazoline (IPO) ligand, in which the iminopyridine group is proposed to stabilize the iron and chiral oxazoline group to control enantioselectivity. This distinct class of reactive IPO ligands will likely be of high value for a large variety of asymmetric transformations using first-row transition metals.
报道了使用新型手性亚氨基吡啶恶唑啉（IPO）配体实现的1,1-二取代芳基烯烃的高区域和对映选择性铁催化反马氏硼氢化反应，其中亚氨基吡啶基团用于稳定铁，手性恶唑啉基团用于控制对映选择性。这类独特的活性IPO配体对于使用第一行过渡金属的多种不对称转化可能具有很高的价值。
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