锰催化芳基酮的不对称硅氢化反应
Manganese-Catalyzed Asymmetric Hydrosilylation of Aryl Ketones.
作者信息
Ma Xiaochen, Zuo Ziqing, Liu Guixia, Huang Zheng
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032, China.
出版信息
ACS Omega. 2017 Aug 18;2(8):4688-4692. doi: 10.1021/acsomega.7b00713. eCollection 2017 Aug 31.
We disclose the synthesis of a series of manganese complexes of chiral iminopyridine oxazoline ligands and their application in the first manganese-catalyzed asymmetric ketone hydrosilylations. The most sterically hindered manganese catalyst bearing two CH(Ph) groups at the 2,6-ortho positions of the imino aryl ring and a Bu group on the oxazoline ring furnishes the secondary alcohols in high enantioselectivities and yields.
我们报道了一系列手性亚氨基吡啶恶唑啉配体的锰配合物的合成及其在首例锰催化的不对称酮硅氢化反应中的应用。在亚氨基芳环的2,6-邻位带有两个CH(Ph)基团且在恶唑啉环上带有一个Bu基团的空间位阻最大的锰催化剂，能以高对映选择性和产率得到仲醇。
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