1st Department of Propaedeutic Surgery, Hippokratio Hospital, University of Athens, Greece.
1st Department of Propaedeutic Surgery, Hippokratio Hospital, University of Athens, Greece.
Int J Surg. 2015 Jan;13:42-48. doi: 10.1016/j.ijsu.2014.11.030. Epub 2014 Nov 28.
The readmission of molecular oxygen into an ischemic tissue promotes the oxidation of resuscitated tissue with certain pathophysiologic mechanisms.
Twenty four pigs (male or female) were randomized in this study. The animals were allocated to four groups with an equal number (n = 6) in each group: (1) control group-ischemia for 30 min and reperfusion for 60 min. (2) control group-ischemia for 30 min and reperfusion for 120 min. (3) ischemia for 30 min and immediate iv injection of lazaroid U-74389G and reperfusion for 60 min. (4) ischemia for 30 min and immediate iv injection of lazaroid U-74389G and reperfusion for 120 min.
We investigated further the role of an antioxidant molecule such as U-74389G and we concluded that there is statistically significant relation in MDA (malondialdeyde), TNF -α (tumor necrosis factor-α) measurement in tissue, while the histological score in the groups that the lazaroid was administered was improved.
In many emergency clinical situations, such as reperfusion of the intestine, the role of U-74389G can be protective.
将分子氧重新引入缺血组织会促进某些病理生理机制下复苏组织的氧化。
本研究纳入了 24 头猪（雄性或雌性），并将其随机分为四组，每组 6 头：（1）对照组-缺血 30 分钟，再灌注 60 分钟。（2）对照组-缺血 30 分钟，再灌注 120 分钟。（3）缺血 30 分钟，立即静脉注射拉扎罗伊德 U-74389G，再灌注 60 分钟。（4）缺血 30 分钟，立即静脉注射拉扎罗伊德 U-74389G，再灌注 120 分钟。
我们进一步研究了抗氧化分子如 U-74389G 的作用，我们得出结论，在组织中 MDA（丙二醛）和 TNF-α（肿瘤坏死因子-α）测量方面存在统计学上的显著关系，而在给予拉扎罗伊德的组中，组织学评分得到了改善。
在许多紧急临床情况下，如肠道再灌注，U-74389G 的作用可能具有保护作用。
